Article Data

  • Views 335
  • Dowloads 141

Original Research

Open Access

Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death

  • Xianfeng Ma1
  • Wan Liu2,*,

1Department of Splenogastric Oncology, Daqing Hospital of Traditional Chinese Medicine, 163000 Daqing, Heilongjiang, China

2Department of Obstetrics and Gynecology, The First Hospital of Yulin, 718000 Yulin, Shaanxi, China

DOI: 10.22514/ejgo.2024.054 Vol.45,Issue 3,June 2024 pp.114-121

Submitted: 15 April 2024 Accepted: 20 May 2024

Published: 15 June 2024

*Corresponding Author(s): Wan Liu E-mail:


Endometrial cancer (EC) is a type of malignant tumor with increasing global incidence and mortality rates, especially in regions with high rates of obesity. Polygonatum sibiricum polysaccharide (PSP) has shown promise in addressing deficiencies associated with EC. While PSP has demonstrated anti-cancer properties across various cancer types, its efficacy in EC remains underexplored. This study investigates the inhibitory effects of PSP on EC cell proliferation and autophagy. Our data demonstrate that PSP effectively inhibits the growth of EC cells and induces apoptosis. Furthermore, PSP triggers autophagy in EC cells. Mechanistically, PSP suppresses the Toll-like receptors (TLR4)/Signal Transducer and Activator of Transcription 3 (STAT3) pathway, thereby inhibiting EC progression. In conclusion, our findings highlight the significant therapeutic potential of PSP in EC treatment by inhibiting cell growth, inducing apoptosis, and triggering autophagy via the TLR4/STAT3 pathway.


Endometrial cancer (EC); Polysaccharide (PSP); Autophagy; Apoptosis; TLR4/STAT3

Cite and Share

Xianfeng Ma,Wan Liu. Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death. European Journal of Gynaecological Oncology. 2024. 45(3);114-121.


[1] Makker V, MacKay H, Ray-Coquard I, Levine DA, Westin SN, Aoki D, et al. Endometrial cancer. Nature Reviews Disease Primers. 2021; 7: 88.

[2] Lu KH, Broaddus RR. Endometrial cancer. New England Journal of Medicine. 2020; 383: 2053–2064.

[3] Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. Endometrial cancer. The Lancet. 2022; 399: 1412–1428.

[4] You JS, Huang Y, Cai YF, Guo JW, Liang WX, Huang PX, et al. Characteristics of traditional Chinese medicine syndromes in patients with acute ischemic stroke of yin or yang syndrome: a multicenter trial. Journal of Chinese Integrative Medicine. 2008; 6: 346–351. (In Chinese)

[5] Shen F, Song Z, Xie P, Li L, Wang B, Peng D, et al. Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage. Journal of Ethnopharmacology. 2021; 275: 114164.

[6] Cui X, Wang S, Cao H, Guo H, Li Y, Xu F, et al. A review: the bioactivities and pharmacological applications of polygonatum sibiricum polysaccharides. Molecules. 2018; 23: 1170.

[7] Xu Y, Guo Y, Lu C, Yu L, Fang C, Li C. Polygonatum sibiricum polysaccharide inhibited liver cancer in a simulated tumor microenvironment by eliminating TLR4/STAT3 pathway. Biological and Pharmaceutical Bulletin. 2023; 46: 1249–1259.

[8] Li M, Liu Y, Zhang H, Liu Y, Wang W, You S, et al. Anti-cancer potential of polysaccharide extracted from polygonatum sibiricum on HepG2 cells via cell cycle arrest and apoptosis. Frontiers in Nutrition. 2022; 9: 938290.

[9] Han X, Zheng J, Zhang L, Zhao Z, Cheng G, Zhang W. Endometrial microbial dysbiosis and metabolic alteration promote the development of endometrial cancer. To be published in International Journal of Gynaecology and Obstetrics. 2024. [Preprint].

[10] Long T, Liu Z, Shang J, Zhou X, Yu S, Tian H, et al. Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-kB signaling pathways. International Journal of Biological Macromolecules. 2018; 111: 813–821.

[11] Huang S, Yuan H, Li W, Liu X, Zhang X, Xiang D, et al. Polygonatum sibiricum polysaccharides protect against MPP-induced neurotoxicity via the Akt/mTOR and Nrf2 pathways. Oxidative Medicine and Cellular Longevity. 2021; 2021: 8843899.

[12] Cai JL, Li XP, Zhu YL, Yi GQ, Wang W, Chen XY, et al. Polygonatum sibiricum polysaccharides (PSP) improve the palmitic acid (PA)-induced inhibition of survival, inflammation, and glucose uptake in skeletal muscle cells. Bioengineered. 2021; 12: 10147–10159.

[13] Rakesh R, PriyaDharshini LC, Sakthivel KM, Rasmi RR. Role and regulation of autophagy in cancer. BBA Molecular Basis of Disease. 2022; 1868: 166400.

[14] Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navas D. Autophagy in the physiological endometrium and cancer. Autophagy. 2021; 17: 1077–1095.

[15] Lupi LA, Cucielo MS, Silveira HS, Gaiotte LB, Cesario RC, Seiva FRF, et al. The role of toll-like receptor 4 signaling pathway in ovarian, cervical, and endometrial cancers. Life Sciences. 2020; 247: 117435.

[16] Ulbrich F, Lerach T, Biermann J, Kaufmann KB, Lagreze WA, Buerkle H, et al. Argon mediates protection by interleukin-8 suppression via a TLR2/TLR4/STAT3/NF-kB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia-reperfusion injury in rat retina in vivo. Journal of Neurochemistry. 2016; 138: 859–873.

[17] Tang D, Su W, Wang X, Chu Z, Zhang L, Zhou J, et al. Clinicopathologic significance of MYD88 L265P mutation and expression of TLR4 and P-STAT3 in primary central nervous system diffuse large B-cell lymphomas. Brain Tumor Pathology. 2021; 38: 50–58.

[18] Paskett ED, Bernardo BM. Eliminating disparities in endometrial cancer: adherence to high-quality care is not enough. American Journal of Obstetrics and Gynecology. 2020; 223: 309–311.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time