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Original Research

Open Access

Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death

  • Xianfeng Ma1
  • Wan Liu2,*,

1Department of Splenogastric Oncology, Daqing Hospital of Traditional Chinese Medicine, 163000 Daqing, Heilongjiang, China

2Department of Obstetrics and Gynecology, The First Hospital of Yulin, 718000 Yulin, Shaanxi, China

DOI: 10.22514/ejgo.2024.054 Vol.45,Issue 3,June 2024 pp.114-121

Submitted: 15 April 2024 Accepted: 20 May 2024

Published: 15 June 2024

*Corresponding Author(s): Wan Liu E-mail: liuwan1770@163.com

Abstract

Endometrial cancer (EC) is a type of malignant tumor with increasing global incidence and mortality rates, especially in regions with high rates of obesity. Polygonatum sibiricum polysaccharide (PSP) has shown promise in addressing deficiencies associated with EC. While PSP has demonstrated anti-cancer properties across various cancer types, its efficacy in EC remains underexplored. This study investigates the inhibitory effects of PSP on EC cell proliferation and autophagy. Our data demonstrate that PSP effectively inhibits the growth of EC cells and induces apoptosis. Furthermore, PSP triggers autophagy in EC cells. Mechanistically, PSP suppresses the Toll-like receptors (TLR4)/Signal Transducer and Activator of Transcription 3 (STAT3) pathway, thereby inhibiting EC progression. In conclusion, our findings highlight the significant therapeutic potential of PSP in EC treatment by inhibiting cell growth, inducing apoptosis, and triggering autophagy via the TLR4/STAT3 pathway.


Keywords

Endometrial cancer (EC); Polysaccharide (PSP); Autophagy; Apoptosis; TLR4/STAT3


Cite and Share

Xianfeng Ma,Wan Liu. Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death. European Journal of Gynaecological Oncology. 2024. 45(3);114-121.

References

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