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Original Research

Open Access

Effect of epirubicin combined with docetaxel on inflammatory factors, cytokines, tumor markers, clinical efficacy and adverse reactions in patients with cervical cancer after surgery

  • Rong Lu1,†
  • Qianqian Feng1,*,†,
  • Jian Yang1
  • Yan Ma1

1Department of Gynaecology, Suzhou Municipal Hospital, 215000 Suzhou, Jiangsu, China

DOI: 10.22514/ejgo.2024.059 Vol.45,Issue 3,June 2024 pp.160-166

Submitted: 05 December 2023 Accepted: 28 May 2024

Published: 15 June 2024

*Corresponding Author(s): Qianqian Feng E-mail: qian_qfeng0213@163.com

† These authors contributed equally.

Abstract

To investigate the clinical efficacy of epirubicin combined with docetaxel in postoperative patients with cervical cancer. A total of 124 postoperative cervical cancer patients were randomly allocated into two groups: the control group (n = 62) and the experimental group (n = 62), using a random number table. Patients in both groups underwent extensive hysterectomy, pelvic nerve-sparing lymphadenectomy, and other surgical interventions as deemed necessary. Postoperatively, the control group received intravenous epirubicin, while the experimental group received intravenous docetaxel in addition to epirubicin. After 3 courses of treatment, the serum levels of interleukin-2 (IL-2), IL-6, IL-4 and interferon γ (IFN-γ) in the experimental group were lower than that in the control group. The levels of IL-2/IL-6, IFN-γ/IL-4, IL-2/IL-4 and IFN-γ/IL-6 were lower than that in the control group. The serum levels of carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag) were lower than that in the control group. The disease control rate was 74.19% (46/62), higher than 56.45% (35/62) in the control group. The incidence of adverse reactions was 6.45% (4/62), lower than 19.35% (12/62) in the control group. The combination of epirubicin and docetaxel demonstrates efficacy in the treatment of postoperative cervical cancer.


Keywords

Epirubicin; Docetaxel; Postoperative cervical cancer; Clinical efficacy


Cite and Share

Rong Lu,Qianqian Feng,Jian Yang,Yan Ma. Effect of epirubicin combined with docetaxel on inflammatory factors, cytokines, tumor markers, clinical efficacy and adverse reactions in patients with cervical cancer after surgery. European Journal of Gynaecological Oncology. 2024. 45(3);160-166.

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