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Unraveling the mystery of uterine cotyledonoid dissecting leiomyoma: a case report

  • Kimia Motlagh Asghari1
  • Ali Dastranj Tabrizi2,*,
  • Pari Seyyed Madani3

1Immunology Research Center, Tabriz University of Medical Sciences, 15731 Tabriz, Iran

2Pathology Department, Tabriz University of Medical Sciences, 5165665931 Tabriz, Iran

3Clinical Research Development Unit of Tabriz Valiasr Hospital, 51665118 Tabriz, Iran

DOI: 10.22514/ejgo.2024.060 Vol.45,Issue 3,June 2024 pp.167-172

Submitted: 18 October 2023 Accepted: 09 November 2023

Published: 15 June 2024

*Corresponding Author(s): Ali Dastranj Tabrizi E-mail:


Cotyledonoid Dissecting Leiomyoma is a rare condition that can be presented as a malignant tumor and may be challenging to diagnose for gynecologists, radiologists and pathologists. We report a case of this tumor in a 40-year-old woman better to understand its clinical, surgical and pathologic features and explore its diagnostic and treatment aspects. The patient presented with chronic suprapubic pain for over two years, while the clinical, radiological and surgical findings were worrisome. In our case, the histopathological examination did not reveal any malignant features, confirming the benign nature of CDL. Positive staining for desmin and caldesmon confirmed the smooth muscle nature of this tumor, and the absence of coagulative tumor cell necrosis, nuclear atypia and absence of increased mitotic activity ruled out leiomyosarcoma. This rare case report provides distinctive patient’s clinical presentation, diagnostic workup, surgical intervention and histopathological findings.


Cotyledonoid dissecting leiomyoma; Cotyledonoid; Dissecting; Leiomyoma; Uterine tumor; Desmin; H-Caldesmon; Case report

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Kimia Motlagh Asghari,Ali Dastranj Tabrizi,Pari Seyyed Madani. Unraveling the mystery of uterine cotyledonoid dissecting leiomyoma: a case report. European Journal of Gynaecological Oncology. 2024. 45(3);167-172.


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