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Rare presentation of cervical choriocarcinoma with metastasis: a case report

  • Javeria Haider1,*,
  • Humera Mahmood1
  • Muhammad Faheem1
  • Shaista Khurshid1
  • Abdullah2

1Department of Oncology, Atomic Energy Cancer Hospital NORI, 44000 Islamabad, Pakistan

2Department of Medicine, Rawalpindi Medical University, 44000 Rawalpindi, Pakistan

DOI: 10.22514/ejgo.2025.103 Vol.46,Issue 7,July 2025 pp.124-127

Submitted: 20 October 2024 Accepted: 06 December 2024

Published: 15 July 2025

*Corresponding Author(s): Javeria Haider E-mail: snaeem1959@gmail.com

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Abstract

Background: Choriocarcinoma of the cervix is an extremely rare sporadic disease with an incidence of 0.76 to 4%. This malignant form of gestational trophoblastic disease typically originates in the uterus but can occasionally arise in the vagina, fallopian tubes, vulva, cervix or pelvic region. Case: Our patient presented with heavy menstrual bleeding and elevated B-Human Chorionic Gonadotropin (B-HCG) levels. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO). Histopathological diagnosis confirmed choriocarcinoma and a post-surgery Computed Tomography (CT) scan revealed lung metastasis. Treatment usually involves combination chemotherapy, which is highly effective, with cure rates reaching 100% in low-risk patients and 80–90% in high-risk patients. Conclusions: This report highlights the importance of a meticulous, multidisciplinary approach in managing patients who present with choriocarcinoma at unusual sites like cervix that can easily be missed and misdiagnosed.


Keywords

Choriocarcinoma; Systemic chemotherapy; Gestational trophoblastic disease


Cite and Share

Javeria Haider,Humera Mahmood,Muhammad Faheem,Shaista Khurshid,Abdullah. Rare presentation of cervical choriocarcinoma with metastasis: a case report. European Journal of Gynaecological Oncology. 2025. 46(7);124-127.

URL:

https://www.ejgo.net/articles/10.22514/ejgo.2025.103

References

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[10] Najib FS, Shiravani Z, Hajisafari M, Moradi Alamdarloo S, Hashemi A, Razavi B, et al. An unusual presentation of choriocarcinoma: a case report with a long latent period. International Journal of Cancer Management. 2021; 14: e103802.

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