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Ovarian cancer think tank: the use of integrated artificial intelligence and computational biology in ovarian cancer diagnosis and treatment

  • Eseohi Ehimiaghe1,*,
  • Hannah Dimmick2
  • Daniel Spinosa1
  • Freda Ireigbe1
  • Miriam D. Post3
  • Rebecca J. Wolsky3
  • Aaron Clauset4,5
  • Sandra Orsulic6,7,8
  • Sarah Taylor9
  • Elena W. Y. Hsieh10,11
  • Natalie Davidson2
  • Marie Wood12
  • Benjamin G. Bitler2
  • Bradley R. Corr1
  • Saketh R. Guntupalli1
  • Lindsay W. Brubaker1
  • Marisa R. Moroney1
  • Kian Behbakht1,2

1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

2Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

3Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

4Department of Computer Science, University of Colorado, Boulder, CO 80310, USA

5BioFrontiers Institute, University of Colorado, Boulder, CO 80303, USA

6Department of Obstetrics and Gynecology and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

7Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90024, USA

8Department of Veterans Affairs, Greater Los Angeles Healthcare System, Los Angeles, CA 90025, USA

9Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, University of Pittsburgh, Pittsburgh, PA 15213, USA

10Department of Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

11Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

12Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA

DOI: 10.22514/ejgo.2026.002 Vol.47,Issue 1,January 2026 pp.15-20

Submitted: 02 September 2025 Accepted: 31 October 2025

Published: 15 January 2026

*Corresponding Author(s): Eseohi Ehimiaghe E-mail: eseohi.ehimiaghe@cuanschutz.edu

Abstract

Artificial intelligence and computational biology are rapidly advancing, offering unprecedented opportunities to transform both ovarian cancer research and clinical care. However, limited understanding of how to optimally integrate the information these tools provide with existing clinical data has led to a lag in integration. This commentary emerges from a unique and focused ovarian cancer research conference that explored how these emerging tools and technologies (i.e., artificial intelligence and computational biology) can be leveraged to address questions in pathology, develop new paradigms of tumor biology, and integrate precision medicine into clinical management of complex and rare subtypes of ovarian cancer. We highlight key ways in which systematic integration of Artificial intelligence (AI) and computational tools can be leveraged to improve outcomes in ovarian cancer as well as the limitations and risks of their application.


Keywords

Computational biology; Ovarian cancer; Artificial intelligence; Tumor microenvironment; Pathobiology; Machine learning; Carcinosarcoma


Cite and Share

Eseohi Ehimiaghe,Hannah Dimmick,Daniel Spinosa,Freda Ireigbe,Miriam D. Post,Rebecca J. Wolsky,Aaron Clauset,Sandra Orsulic,Sarah Taylor,Elena W. Y. Hsieh,Natalie Davidson,Marie Wood,Benjamin G. Bitler,Bradley R. Corr,Saketh R. Guntupalli,Lindsay W. Brubaker,Marisa R. Moroney,Kian Behbakht. Ovarian cancer think tank: the use of integrated artificial intelligence and computational biology in ovarian cancer diagnosis and treatment. European Journal of Gynaecological Oncology. 2026. 47(1);15-20.

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