A systematic study of nursing interventions for the gynecologic cancer among women

Background: This study systematically reviewed nursing interventions for women with gynaecological cancers to provide empirical evidence for developing evidence-based, patient-centered nursing care. Methods: A comprehensive literature search was conducted across both domestic and international databases, including PubMed, Embase, CINAHL Database, Cochrane, ProQuest, DBpia, the Korean Studies Information Service System (KISS), and the Research Information Sharing Service (RISS). The search covered studies published from January 2015 to February 2024 and utilized MeSH (Medical Subject Headings) terms, such as “gynaecological cancer” and “nursing intervention”. Seven randomized controlled trials and clinical trials with control groups were selected. The types, components, outcome measures, and study designs of the nursing interventions were analyzed using the Population, Intervention, Comparison, and Outcome (PICO) framework. Results: Identified nursing interventions included exercise therapy, cognitive behavioral therapy, mindfulness, telemedicine, sexual health programs, and reflexology. Common outcome measures were anxiety, depression, fatigue, pain, sexual dysfunction, self-efficacy, and quality of life. Nurse-led interventions, particularly those focusing on sexual rehabilitation and psychosocial support, demonstrated significant improvements in patient outcomes. Conclusions: Nursing interventions have proven effective in improving symptom management, psychological well-being, sexual health, and quality of life in women with gynaecological cancer. Future research should focus on standardizing intervention protocols, conducting multicenter clinical trials, and integrating qualitative research to enhance the evidence base. The PROSPERO Registration: CRD420251148600.

Gynaecological cancer; Nursing interventions; Patient-centered care; Quality of life; Evidence-based practice

[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2021; 71: 209–249.

[2] National Cancer Information Center. Annual report of cancer statistics in Korea in 2023. 2025. Available at: https://www.cancer.go.kr (Accessed: 10 July 2025).

[3] Hyeon S, Lee J, Yang S, Hong B. Nurse-led digital health intervention in post-discharge cancer patients: a scoping review. Asian Oncology Nursing. 2024; 24: 228.

[4] Zhang Q, Li F, Zhang H, Yu X, Cong Y. Effects of nurse-led home-based exercise and cognitive behavioral therapy on reducing cancer-related fatigue in patients with ovarian cancer during and after chemotherapy: a randomized controlled trial. International Journal of Nursing Studies. 2018; 78: 52–60.

[5] Xunlin N, Lau Y, Klainin-Yobas P. The effectiveness of mindfulness-based interventions among cancer patients and survivors: a systematic review and meta-analysis. Supportive Care in Cancer. 2020; 28: 1563–1578.

[6] Yang M, Hong A, Qin M, Gu X, Yuan C. The role of nursing interventions in the management and outcomes of gynecological tumors: a systematic review and meta-analysis. Supportive Care in Cancer. 2025; 33: 705.

[7] Wang T, Tang C, Jiang X, Guo Y, Zhu S, Xu Q. Effectiveness of web-based mindfulness-based interventions for patients with cancer: systematic review and meta-analyses. Journal of Medical Internet Research. 2024; 26: e47704.

[8] Schofield P, Gough K, Pascoe M, Bergin R, White K, Mileshkin L, et al. A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: the PeNTAGOn randomised controlled trial—ANZGOG 1102. Gynecologic Oncology. 2020; 159: 785–793.

[9] Cafforio P, Palmirotta R, Lovero D, Cicinelli E, Cormio G, Silvestris E, et al. Liquid biopsy in cervical cancer: hopes and pitfalls. Cancers. 2021; 13: 3968.

[10] Kliuchnikova A, Gordeeva A, Abdurakhimov A, Materova T, Tarbeeva S, Sarygina E, et al. Ovarian cancer: multi-omics data integration. International Journal of Molecular Sciences. 2025; 26: 5961.

[11] Chen CY, Li SN, Li XX, Zhou B. Mindfulness-based interventions in oncology: a scoping review of outcomes and applications. World Journal of Clinical Cases. 2025; 13: 106864.

[12] Tivey A, Lee RJ, Clipson A, Hill SM, Lorigan P, Rothwell DG, et al. Mining nucleic acid “omics” to boost liquid biopsy in cancer. Cell Reports. Medicine. 2024; 5: 101736.

[13] Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. The BMJ. 2021; 372: n71.

[14] Kim HO, Lim KH. Effects of foot bath therapy on peripheral neuropathy, sleep disorder, and fatigue in gynaecological patients with cancer undergoing chemotherapy. Korean Journal of Adult Nursing. 2021; 33: 472. (In Korean)

[15] Lee B, Park H. Effects of telephone-based self-care intervention for gynecological cancer patients receiving chemotherapy. Journal of Korean Academy of Fundamentals of Nursing. 2023; 30: 216–224. (In Korean)

[16] Noh GO, Park KS. Effects of aroma self-foot reflexology on peripheral neuropathy, peripheral skin temperature, anxiety, and depression in gynaecologic cancer patients undergoing chemotherapy: a randomised controlled trial. European Journal of Oncology Nursing. 2019; 42: 82–89.

[17] Bakker RM, Mens JW, de Groot HE, Tuijnman-Raasveld CC, Braat C, Hompus WC, et al. A nurse-led sexual rehabilitation intervention after radiotherapy for gynecological cancer. Supportive Care in Cancer. 2017; 25: 729–737.

[18] Dikmen HA, Terzioglu F. Effects of reflexology and progressive muscle relaxation on pain, fatigue, and quality of life during chemotherapy in gynecologic cancer patients. Pain Management Nursing. 2019; 20: 47–53.

[19] Olesen ML, Duun-Henriksen AK, Hansson H, Ottesen B, Andersen KK, Zoffmann V. A person-centered intervention targeting the psychosocial needs of gynecological cancer survivors: a randomized clinical trial. Journal of Cancer Survivorship. 2016; 10: 832–841.

[20] Öztürk R, Sevil Ü, Sargin A, Yücebilgin MS. The effects of reflexology on anxiety and pain in patients after abdominal hysterectomy: a randomised controlled trial. Complementary Therapies in Medicine. 2018; 36: 107–112.

[21] Whittemore R, Knafl K. The integrative review: updated methodology. Journal of Advanced Nursing. 2005; 52: 546–553.

[22] Carter J, Penson R, Barakat R, Wenzel L. Contemporary quality of life issues affecting gynecologic cancer survivors. Hematology/Oncology Clinics of North America. 2011; 26: 169–194.

[23] Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M; Medical Research Council Guidance. Developing and evaluating complex interventions: the new Medical Research Council guidance. The BMJ. 2008; 337: a1655.

[24] Lawler M, De Lorenzo F, Lagergren P, Mennini FS, Narbutas S, Scocca G, et al.; European Academy of Cancer Sciences. Challenges and solutions to embed cancer survivorship research and innovation within the EU Cancer Mission. Molecular Oncology. 2021; 15: 1750–1758.

[25] Huffman LB, Hartenbach EM, Carter J, Rash JK, Kushner DM. Maintaining sexual health throughout gynecologic cancer survivorship: a comprehensive review and clinical guide. Gynecologic Oncology. 2016; 140: 359–368.

[26] Wenzel LB, Donnelly JP, Fowler JM, Habbal R, Taylor TH, Aziz N, et al. Resilience, reflection, and residual stress in ovarian cancer survivorship: a gynecologic oncology group study. Psycho-Oncology. 2002; 11: 142–153.

[27] Breistig S, Thorkildsen KM, Tveit Sekse RJ. Gynecological cancer survivors’ experiences and desire for follow-up after recent treatment: a phenomenological hermeneutic study. Cancer Nursing. 2024; 47: E327–E335.