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Poorly differentiated ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcomatous elements associated with elevated serum alpha-fetoprotein level: a case report and review of the literature

  • Z. Hao1
  • S. Yang1,*,
  • X. Deng2

1Department of Gynecology, Affiliated Hospital of Medical School, Ningbo University

2Diagnostic Pathology Center, Ningbo city (China)

DOI: 10.31083/j.ejgo.2020.01.4806 Vol.41,Issue 1,February 2020 pp.138-141

Published: 15 February 2020

*Corresponding Author(s): S. Yang E-mail:


Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord–stromal tumors. Moreover, SLCTs with heterologous mesenchymal elements are extremely rare and usually associated with poor differentiation and prognosis. Herein, the authors describe a case of SLCT involving the right ovary in a 16-year-old girl who presented with acute lower abdominal pain and fever. Serum investigation demonstrated abnormally elevated level of alpha-fetoprotein (AFP), slightly elevation of testosterone, and CA125 concentration. Right salpingo-oopherectomy was performed due to ovarian tumor torsion and then histopathological analysis revealed a poorly differentiated Sertoli-Leydig cell tumor with heterologous rhabdomyosarcomatous elements. A brief review of the literature was conducted to explore the management options for patients with SLCTs and the prognosis.


Ovary; Sertoli-Leydig cell tumors; Sex cord-stromal tumors; Rhabdomyosarcoma; Alpha fetoprotein.

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Z. Hao,S. Yang,X. Deng. Poorly differentiated ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcomatous elements associated with elevated serum alpha-fetoprotein level: a case report and review of the literature. European Journal of Gynaecological Oncology. 2020. 41(1);138-141.


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