Secondary small cell carcinoma of the endometrium after concurrent chemoradiotherapy for cervical cancer: a rare case

Background: Small cell carcinoma of the endometrium is extremely rare. There is no reported case of secondary small cell carcinoma of the endometrium after concurrent chemoradiotherapy for cervical cancer. Case Report: A 48-year-old woman was diagnosed with squamous cell carcinoma of the cervix Stage IIIB (T3bN0M0) and treated by concurrent chemoradiotherapy. After five years and nine months’ post-treatment, the woman was diagnosed with small cell carcinoma of the endometrium Stage IIIA (pT3aNXM0). Although the patient received chemotherapy combining paclitaxel and carboplatin postoperatively, she developed a recurrence with pelvic tumor three months after operation. After recurrence, she received one course of chemotherapy combining cisplatin and irinotecan. Although a remarkable reduction of recurrent tumor was found as autopsy findings, she died of disease two months after this chemotherapy. Conclusion: In case of small cell carcinoma of the endometrium, chemotherapy regimen used for small cell lung cancer such as chemotherapy combining cisplatin and irinotecan should be considered.

Secondary small cell carcinoma of the endometrium; Concurrent chemoradiotherapy; Cervical cancer.

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