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HMGCR antibody-associated myopathy in patient with endometrial cancer: a rare case

  • T. Wada1
  • Y. Hashiguchi1,*,
  • M. Kasai1
  • T. Fukuda1
  • T. Ichimura1
  • T. Yasui1
  • T. Sumi1

1Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka (Japan)

DOI: 10.31083/j.ejgo.2020.01.4901 Vol.41,Issue 1,February 2020 pp.148-150

Published: 15 February 2020

*Corresponding Author(s): Y. Hashiguchi E-mail:


Background: Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody (HMGCR antibody) antibody-associated myopathy is a rare disease. HMGCR antibody-associated myopathy in patient with endometrial cancer is extremely rare. Case Report: A 60-year-old woman without statin exposure presented with endometrial cancer Stage IIIC1 (T2N1M0) and HMGCR antibody-associated myopathy. After diagnosis, the patient received chemotherapy combining paclitaxel and carboplatin for endometrial cancer, and steroid and immunoglobulin for HMGCR antibody-associated myopathy. Two months after two cycles of chemotherapy, she died. Autopsy revealed that she died of HMGCR antibody-associated myopathy. Conclusion: In case of myopathy in patients with endometrial cancer, HMGCR antibody-associated myopathy should be considered.


Endometrial cancer; HMGCR antibody-associated myopathy.

Cite and Share

T. Wada,Y. Hashiguchi,M. Kasai,T. Fukuda,T. Ichimura,T. Yasui,T. Sumi. HMGCR antibody-associated myopathy in patient with endometrial cancer: a rare case. European Journal of Gynaecological Oncology. 2020. 41(1);148-150.


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[5] Tsujikawa K., Hara K., Muro Y., Nakanishi H., Niwa Y., Koike M., et al.: “HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma.” Neurology, 2016, 87, 841.

[6] Kadoya M., Hida A., Hashimoto Maeda M., Taira K., Ikenaga C., Uchio N., et al.: “Cancer association as a risk factor for antiHMGCR antibody-positive myopathy.” Neurol. Neuroimmunol. Neuroinflamm., 2016, 3, e290.

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