Article Data

  • Views 708
  • Dowloads 116

Case Reports

Open Access

Uterine adenosarcoma admixed with a primitive neuroectodermal tumour (PNET): a case report and review of the literature

  • I. Pecorella1,*,
  • F. Alesini1
  • F. Gianno1
  • A. Tornese1
  • V. Colagiovanni1
  • M. Monti1

1Department of Radiological, Oncological and Anatomical Pathology Sciences, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena, Rome

2Department of Gynaecological, Obstetrical and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, Viale del Policlinico Rome (Italy)

DOI: 10.31083/j.ejgo.2020.01.5059 Vol.41,Issue 1,February 2020 pp.110-115

Published: 15 February 2020


*Corresponding Author(s): I. Pecorella E-mail:


Herein the authors report a case of uterine adenosarcoma admixed with primitive neuroectodermal tumour (PNET) and review the literature on these rare neoplasms, as well as data files of their Gynaecologic Pathology Centre in Rome, Italy.


Uterine adenosarcoma; Primitive neuroectodermal tumour (PNET).

Cite and Share

I. Pecorella,F. Alesini,F. Gianno,A. Tornese,V. Colagiovanni,M. Monti. Uterine adenosarcoma admixed with a primitive neuroectodermal tumour (PNET): a case report and review of the literature. European Journal of Gynaecological Oncology. 2020. 41(1);110-115.


[1] Pinto A., Howitt B.: “Uterine adenosarcoma”. Arch. Pathol. Lab. Med., 2016, 140, 286.

[2] Shi Y., Liu Z., Peng Z., Liu H., Yang K., Yao X.: “The diagnosis and treatment of Mullerian adenosarcoma of the uterus”. Austr. New Zealand J. Obstet. Gynaecol., 2008, 48, 596.

[3] Akbayir O., Gungorduk K., Rafioglu G., Gulkilik A., Yavuz E., Tekirdag A.I., et al.: “Primary primitive neuroectodermal tumor of the uterus: A case report”. Arch. Gynecol. Obstet., 2008, 277, 345.

[4] Euscher E.D., Deavers M.T., Lopez-Terrada D., Lazar A.J., Silva E.G., Malpica A.: “Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature”. Am. J. Surg. Pathol., 2008, 32, 219.

[5] Fadare O.: “Heterologous and Rare Homologous Sarcomas of the Uterine Corpus: A Clinicopathologic Review”. Adv. Anat. Pathol., 2011, 18, 60.

[6] Creasman W.T., Odicino F., Maisonneuve P., Quinn M.A., Beller U., Benedet J.L., et al.: “Carcinoma of the corpus uteri. FIGO 26th annual report on the results of treatment in gynecological cancer”. Int. J. Gynaecol. Obstet., 2006, 95, 105.

[7] Bartosch C., Vieira J., Teixeira M.R., Lopes J.M.: “Endometrial endometrioid adenocarcinoma associated with primitive neuroectodermal tumor of the uterus: a poor prognostic subtype of uterine tumors”. Med. Oncol., 2011, 28, 1488.

[8] Bhardwaj M., Batrani M., Chawla I., Malik R.: “Uterine primitive neuroectodermal tumor with adenosarcoma: a case report”. J. Med. Case Rep., 2010, 4, 195.

[9] Dundr P., Fischerová D., Povýšil C., Berková A., Bauerová L., Cibula D.: “Uterine tumors with neuroectodermal differentiation. A report of 4 cases”. Pathol. Oncol. Res., 2010, 16, 601.

[10] Daya D., Lukka H., Clement P.B.: “Primitive neuroectodermal tumors of the uterus; a report of four cases”. Hum. Pathol., 1992, 23, 1120.

[11] Sinkre P., Albores-Saavedra J., Miller D.S., Copeland L.J., Hameed A.: “Endometrial endometrioid carcinomas associated with Ewing sarcoma/peripheral primitive neuroectodermal tumor”. Int. J. Gynecol. Pathol., 2000, 19, 127.

[12] Quddus M.R., Rashid L., Sung C.J., Steinhoff M.M., Zhang C., Lawrence W.D.: “Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas”. Reprod Sci., 2009, 16, 591.

[13] Cate F., Bridge J.A., Crispens M.A., Keedy V.L., Troutman A., Coffin C.M., Fadare O.: “Composite uterine neoplasm with embryonal rhabdomyosarcoma and primitive neuroectodermal tumor components: rhabdomyosarcoma with divergent differentiation, variant of primitive neuroectodermal tumor, or unique entity?” Hum. Pathol., 2013, 44, 656.

[14] Stolniku S., Goyenaga P., Hincu M., Marian C., Murillo R., Nogales F.F.: “Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component”. Int. J. Gynecol. Pathol., 2012, 31, 387

[15] Fukunaga M., Nomura K., Endo Y., Ushigome S., Aizawa S.: “Carcinosarcoma of uterus with extensive neuroectodermal differentiation”. Histopathology, 1996, 29, 565.

[16] Gersell D.J., Duncan D.A., Fulling K.H.: “Malignant mixed mullerian tumor of the uterus with neuroectodermal differentiation”. Int. J. Gynecol. Pathol., 1989, 8, 169.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time