Article Data

  • Views 627
  • Dowloads 155

Original Research

Open Access

Development of high-risk HPV associated cervical dysplasia despite HPV-vaccination: a regional dysplasia center cohort study

  • A.K. Fischer1
  • K. Reuter-Jessen2
  • H.-U. Schildhaus2
  • T. Hugo2
  • A.H. Scheel3
  • Merkelbach-Bruse3
  • E. Heinmöller1
  • R. Buettner3
  • B. Jasani4
  • J. Walbeck5
  • J.Rüschoff1,4,*,
  • P.Middel1

1Institute of Pathology Nordhessen, Kassel (Germany)

2Institute of Pathology, University Hospital Göttingen, Göttingen (Germany)

3Institute of Pathology, University Hospital Cologne, Cologne (Germany)

4Targos Molecular Pathology GmbH, Kassel (Germany)

5Regional Dysplasia Clinic Nordhessen, Kassel (Germany)

DOI: 10.31083/j.ejgo.2020.01.5093 Vol.41,Issue 1,February 2020 pp.80-84

Published: 15 February 2020

*Corresponding Author(s): J.Rüschoff E-mail: info@patho-nordhessen.de

Abstract

The present study was conducted to examine the frequency of CIN/squamous intraepithelial lesions in patients after vaccination and respective HPV types observed at their referral to a regional center for screening of cervical dysplasia.

Keywords

HPV; Vaccination; Cervical intraepithelial neoplasia.

Cite and Share

A.K. Fischer,K. Reuter-Jessen,H.-U. Schildhaus,T. Hugo,A.H. Scheel,Merkelbach-Bruse,E. Heinmöller,R. Buettner,B. Jasani,J. Walbeck,J.Rüschoff,P.Middel. Development of high-risk HPV associated cervical dysplasia despite HPV-vaccination: a regional dysplasia center cohort study. European Journal of Gynaecological Oncology. 2020. 41(1);80-84.

References

[1] Munoz N., Bosch, F. X., de Sanjose, S., Herrero, R., Castellsague, X., Shah, K. V., Snijders, et al.: “Epidemiologic classification of human papillomavirus types associated with cervical cancer”. N. Engl. J. Med., 2003, 348, 518.

[2] Tota J.E., Ramana-Kumar A.V, El-Khatib Z., Franco E.L.: “The road ahead for cervical cancer prevention and control”. Curr. Oncol., 2014, 21, e255.

[3] National Cancer Institute: “HPV and Cancer”. available at: www.cancer.gov/about-cancer/causes-prevention/risk/infectiousagents/hpv-fact-sheet

[4] Cid-Arregui A.: “Therapeutic vaccines against human papillomavirus and cervical cancer”. Open Virol. J., 2009, 3, 67.

[5] Delere Y., Wichmann O., Klug S.J., van der Sande M., Terhardt M., Zepp F., Harder T.: “The efficacy and duration of vaccine protection against human papillomavirus: a systematic review and meta-analysis”. Dtsch. Aerztbl. Int., 2014, 111, 584.

[6] Doorbar J., Quint W., Banks L., Bravo I.G., Stoler M., Broker T.R., Stanley M.A.: “The biology and life-cycle of human papillomaviruses”. Vaccine, 2012, 30, F55.

[7] Immunization Expert Work Group, C.o.A.H.C: “Committee opinion No. 704: human papillomavirus vaccination”. Obstet. Gynecol., 2017, 129, e173.

[8] Markowitz L.E., Liu G., Hariri S., Steinau M., Dunne E.F., Unger E.R.: “Prevalence of HPV after introduction of the vaccination program in the United States”. Pediatrics, 2016, 137, e20151968.

[9] Brotherton J.M.L., Fridman M., May C.L., Chappell G., Saville A.M., Gertig D.M.: “Early effect of the HPV vaccination programme on cervical abnormalities in Virctoria, Australia: an ecological study”. Lancet, 2011, 377, 2085.

[10] Robert Koch Institut: “Mitteilung der Ständigen Impfkommission (STIKO) am Robert Koch Institut: Anwendung des neunvalenten Impfstoffs gegen Humane Papillomviren (HPV)”. Epidemiologisches Bull., 2016, 16, 137.

[11] Calil L.N., Edelweiss M.I.A., Meurer L., Ignasi C.N., Bozzetti M.C.: “p16INK4a and Ki67 expression in normal, dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection”. Pathol. Res. Pract., 2014, 210, 482.

[12] Serrano B., Alemany L., Tous S., Bruni L, Clifford G.M., Weiss T., et al.: “Potential inpact of a nine-valent vaccine in human papillomavirus related cervical disease”. Inf. Agents and Cancer, 2012, 7, 38.

[13] Kavanagh K., Pollock K.G.J., Potts A., Love J., Cuschieri K., Cubie H. et al.: “Introduction and sustained high coverage of the HPV bivalent vaccine leads to a reduction in prevalence of HPV 16/18 and closely related HPV types”. Br. J. Cancer, 2014, 110, 2804.

[14] Tabrizi S.N., Brotherton J.M.L., Kaldor J.M., Skinner S.R., Liu B., Bateson D. et al.: “Assessment of herd immunity and cross-protection after a human papillomavirus vaccination programme in Australia: a repeat cross-sectional study”. Lancet Infect. Dis., 2014, 14, 958.

[15] Kirby T.: “FDA approves new upgraded Gardasil 9”. Lancet Oncol., 2015, 16, e56.

[16] Schlecht N.F., Platt R.W., Duarte-Franco E., Costa M.C., Sobrinho J.P., Prado J.C. et al.: “Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia”. J. Natl. Cancer Inst., 2003, 95, 1336.

[17] Donken R., King A.J., Bogaards J.A., Woestenberg P.J., Meijer C.J.L.M, de Melker H.E.: “High effectiveness of the bivalent human papillomavirus (HPV) vaccine against incident and persistent HPV infections up to 6 years after vaccination in young dutch women”. J. Infect. Dis, 2018, 217, 1579.

[18] Massad L.S.: “Anticipating the impact of human papillomavirus vaccination on US cervical cancer prevention strategies”. J. Low. Genit. Tract Dis., 2018, 22, 123.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top