Negative p53 expression and negative high risk HPV in a 26-year-old lady with vulvar keratinizing squamous cell carcinoma: report of a case
1Jordan University Hospital, Jordan University, Amman
2Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt (Jordan)
DOI: 10.31083/j.ejgo.2020.013.01.4777 Vol.41,Issue 1,February 2020 pp.130-133
Published: 15 February 2020
Vulvar intraepithelial neoplasia (VIN) and human papilloma virus (HPV) are the main pathways for development of vulvar carcinoma in young women. While, non-HPV associated pathway is the usual pattern seen in postmenopausal women. Herein, the authors report a case of 26-year-old lady with keratinizing vulvar squamous cell carcinoma (SCC), in which vulvar intraepithelial neoplasia (VIN) of the simplex type and p53 expression were absent. Moreover, no high risk HPV was detected by the highly sensitive real time-polymerase chain reaction (RT-PCR) technology on the paraffin embedded tumor tissue. Therefore, in addition to the patient’s young age, she had morphologic and molecular patterns that are usually seen in elderly women. The authors believe that this is an unusual presentation in such a very young lady. The cause of this cancer in this case is not completely understood and indicates the necessity to sample any suspicious lesions at this site at any age.
Juvenile vulvar carcinoma; Human papilloma virus; Juvenile keratinizing squamous cell carcinoma; Polymerase chain reaction; Immunohistochemistry.
M.H. Hajeer,A. Al Khader,N.A. Shahin,M.S. Bata. Negative p53 expression and negative high risk HPV in a 26-year-old lady with vulvar keratinizing squamous cell carcinoma: report of a case. European Journal of Gynaecological Oncology. 2020. 41(1);130-133.
 Siegel R.L., Miller K.D., Jemal A.: “ Cancer statistics”. CA Cancer J. Clin., 2016, 66, 7.
 Ueda Y., Enomoto T., Kimura T., Yoshino K., Fujita M., Kimura T.: “Two distinct pathways to development of squamous cell carcinoma of the vulva”. J. Skin Cancer, 2010, 2011, 951250.
 Schuurman M.S., van den Einden L.C., Massuger L.F., Kiemeney L.A., van der Aa M.A., de Hullu J.A.: ”Trends in incidence and survival of Dutch women with vulvar squamous cell carcinoma”. Eur. J. Cancer, 2013, 49, 3872.
 Echeverri C., Stoler M.H., Valente P.T.: “Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman”. Arch. Pathol. Lab. Med., 2001, 125, 267.
 Alkatout I., Schubert M., Garbrecht N., Weigel M.T., Jonat W., Mundhenke C., Günther V.: “Vulvar cancer: epidemiology, clinical presentation, and management options”. Int. J. Womens Health, 2015, 7, 305.
 Wakeham K., Kavanagh K., Cuschieri K., Millan D., Pollock K.G., Bell S., et al.: “HPV status and favourable outcome in vulvar squamous cancer”. Int. J. Cancer., 2017, 140, 1134.
 Kruse A.J., Bottenberg M.J., Tosserams J., Slangen B., van Marion A.M., van Trappen P.O.: “The absence of high-risk HPV combined with specific p53 and p16INK4a expression patterns points to the HPV-independent pathway as the causative agent for vulvar squamous cell carcinoma and its precursor simplex VIN in a young patient”. Int. J. Gynecol. Pathol., 2008, 27, 591.
 Al-Ghamdi A., Freedman D., Miller D., Poh C., Rosin M., Zhang L., Gilks C.B.: “Vulvarsquamous cell carcinoma in youngwomen: a clinicopathologic study of 21 cases”. Gynecol. Oncol., 2002, 84, 94.
 Tapisiz O.L., Topcu O., Gungor T., Ozdal B., Sirvan L., Yesilyurt A.: “Squamous cell carcinoma of the vulva in a virgin patient with Turner syndrome”. J. Gynecol. Oncol., 2011, 22, 211.
 Gómez-Alarcon A., Gómez-García M.T., García-de la-Torre J.P., Del Valle-Morón M., Arones-Collantes M.A., González-de Merlo G.: “Vulvar squamous cell carcinoma in young women with HPV nega- tive”. Ginecol. Obstet. Mex., 2016, 84, 172.
 Uysal P., Onan D., Çolak A., Bozdoğan Ö., Artüz F.: “Neglected Vulvar ‘Dermatitis’ in a Young Woman: A Case of Vulvar Squamous Cell Carcinoma”. J. Turk. Acad. Dermatol., 2016, 10, 16104c5.
 Roman L.D., Mitchell M.F., Burke T.W., Silva E.G.: “Unsuspected invasive squamous cell carcinoma of the vulva in young women”. Gynecol. Oncol., 1991, 41, 182.
 Rao T.M., Bellam S.S., Gurupuprasad P.: “Vulvarinvasive squamous cell carcinoma in a young patient with Human Immunodeficiency Virus-seropositivity”. Indian J. Sex. Transm. Dis., 2015, 36, 204.
 Nguessan K.L., Mian D.B., Kasse K., Boni S.: “Vulvar squamous cell carcinoma developing in ayoung black African HIV woman”. Eur. J. Gynaecol. Oncol., 2013, 34, 496.
 Sekowski A., Ooko F.O., Napo H., Mphahlele R.J.: “HIV-related cancer of the vulva in young women: a clinicopathologic study of five cases”. J. Obstet. Gynaecol., 2008, 28, 555.
 Brown J.E., Sunborg M.J., Kost E., Cosin J.A., Winter W.E. 3rd.: “Vulvar cancer in human immunodeficiency virus-seropositive premenopausal women: a case series and review of the literature”. J. Low. Genit. Tract. Dis., 2005, 9, 7.
 Giaquinto C., Del Mistro A., De Rossi A., Bertorelle R., Giacomet V., Ruga E., Minucci D.: “Vulvar carcinoma in a 12-year-old girl with vertically acquired human immunodeficiency virus infection”. Pediatrics, 2000, 106, e57.
 Hasanzadeh M., Zamiri-Akhlaghi A., Hassanpoor-Moghaddam M., Shahidsales S.: “Vulvar carcinoma in pregnant women aged less than 40 years: case report”. Iran J. Cancer Prev., 2014, 7, 175.
 Heller D.S., Cracchiolo B., Hameed M., May T.: “Pregnancy-associated invasive squamous cell carcinoma of the vulva in a 28-yearold, HIV-negative woman. A case report”. J. Reprod. Med., 2000, 45, 659.
 Keskin N., Iyibozkurt A.C., Topuz S., Salihoğlu Y., Bengisu E., Berkman S.: “Invasive squamous carcinoma of the vulva in women aged less than 40 years: Report of two cases and a third case diagnosed during pregnancy”. Eur. J. Gynaecol. Oncol., 2008, 29, 399.
 Kesterson J., South S., Lele S.: “Squamous cell carcinoma of the vulva in a young womanwith Crohn’s disease”. Eur. J. Gynaecol. Oncol., 2008, 29, 651.
 Piura B., Rabinovich A., Shaco-Levy R., Sukenik S.: ” Vulvar invasive squamous cell carcinoma occurring in a young woman with systemic lupus erythematosus”. Eur. J. Gynaecol. Oncol., 2005, 26, 103.
 Bakour S.H., Jaleel H., Weaver J.B., Kehoe S., Radcliffe K.W.: “Vulvar carcinoma presenting during pregnancy, associated with recurrent bone marrow hypoplasia: a case report and literature review”. Gynecol. Oncol., 2002, 87, 207.
 Mousavi A., Abbasi F., Abadi A.G., Hashemi F.A.: “Vulvar squamous cell carcinoma associated with Fanconi’s anemia”. Int. J. Hematol., 2010, 91, 498.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.