Preserving fertility in patients with granulosa cell tumors of the ovary

Granulosa cell tumors of the ovary are rare ovarian neoplasms developing from ovarian stromal cells. They are characterized by insidious growth, low malignancy potential, and late recurrence. Due to the production of estrogen by these tumors, the frequent symptoms that occur in these patients develop as a result of hyperestrogenism. Standard treatment involves surgery in all patients. Fertility-sparing surgery is considered safe in young patients only in case of early-stage IA and IC tumors, where it is necessary to perform a unilateral salpingo-oophorectomy and complete staging. Surgical staging includes peritoneal washing, multiple peritoneal biopsies, omental biopsy, and biopsy of any suspicious area

Ovarian granulosa cell tumor; Fertility-sparing surgery in patients with granulosa cell tumors

[1] Aymen F.M., Majed G., Hanene C., Joumana L., Amin B.: “Advanced Granulosa Cell Tumor and Pregnancy: A Case Report, How to Treat and How to Preserve Fertility?”. Endocrinol Metab. Syndr., 2016, 5, 250.

[2] Manel Dridi, Nesrine Chraiet, Rim Batti, Mouna Ayadi, Amina Mokrani.: “Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.International Journal of Surgical Oncology”. Int. J. Surg. Oncol., 2018, 2018, 4547892.

[3] Vijaykumar Dehannathparambil Kottarathil, Michelle Aline Antony, Indu R. Nair, Keechilat Pavithran.: “Recent Advances in Granulosa Cell Tumor Ovary: A Review”. Indian J. Surg. Oncol., 2013, 4, 37.

[4] Divya Khosla, Kislay Dimri, Awadhesh K. Pandey, Rohit Mahajan, Romeeta Trehan.: “Ovarian Granulosa Cell Tumor: Clinical Features, Treatment, Outcome, and Prognostic Factors”. N. Am. J. Med. Sci., 2014, 6, 133.

[5] Wang D., Cao D., Jia C., Huang H., Yang J., Wu M., et al.: “Analysis of oncologic and reproductive outcomes after fertility-sparing surgery in apparent stage I adult ovarian granulosa cell tumors”. Gynecol. Oncol., 2018, 151, 275.

[6] Homesley H.D., Bundy B.N., Hurteau J.A., Roth L.M.: “Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study”. Gynecol. Oncol., 1999, 72, 131.

[7] Schumer S.T., Cannistra S.A.: “Granulosa cell tumor of the ovary”. J. Clin. Oncol., 2003, 15, 1180.

[8] Kanthan R., Senger J.L., Kanthan S.: “The multifaceted granulosa cell tumours-myths and realities: A review”. ISRN Obstet. Gynecol., 2012, 2012,878635.

[9] Zhang M., Cheung M.K., Shin J.Y., Kapp D.S., Husain A., Teng N.N., et al.: “Prognostic factors responsible for survival in sex cord stromal tumors of the ovary: an analysis of 376 women”. Gynecol. Oncol., 2007, 104, 396.

[10] Homesley H.D., Bundy B.N., Hurteau J.A., Roth L.M.: “Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study”. Gynecol. Oncol., 1999, 72, 131.

[11] Pautier P., Gutierrez-Bonnaire M., Rey A., Sillet-Bach I., Chevreau C., Kerbrat P., et al.: “Combination of bleomycin, etoposide, and cisplatin for the treatment of advanced ovarian granulosa cell tumors”. Int. J. Gynecol. Cancer, 2008, 18, 446.

[12] Iavazzo C., Gkegkes I.D., Vrachnis N.: “Fertility sparing management and pregnancy in patients with granulosa cell tumour of the ovaries”. J. Obstet. Gynaecol., 2015, 35, 331.