Article Menu

Export Article

More by Authors Links

Article Data

  • Views 784
  • Dowloads 144

Case Reports

Open Access

Neoadjuvant chemotherapy followed by radical surgery for Stage IB2 cervical cancer in pregnancy

  • X.F. Xu1
  • Q. Li1
  • A.Y. Dai1
  • H.J. Zhou1
  • J.X. Ling1,*,

1Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China

DOI: 10.31083/j.ejgo.2020.03.5288 Vol.41,Issue 3,June 2020 pp.489-491

Submitted: 17 June 2019 Accepted: 08 August 2019

Published: 15 June 2020

*Corresponding Author(s): J.X. Ling E-mail: lingjingxiangy@163.com

PDF (523.76 kB)

Abstract

Background: Pregnancy with cervical cancer (CC) represents an important challenge. Case Report: The authors report a case of a 34-year old diagnosed with Stage IB2 squamous cell cervical cancer at 24+-week gestation who was then treated with neoadjuvant chemotherapy followed by cesarean section and radical hysterectomy with good outcome of both the mother and the baby. Conclusion: The results of this case study, combined with previous reports and the authors’ clincal experience, support the combination of paclitaxel and cisplatin for neoadjuvant chemotherapy when treating FIGO Stage IB2 cervical cancer in pregnancy.

Keywords

Cancer; Carcinoma; Chemotherapy; Gynecological cancers; Mid-trimester pregnancy

Cite and Share

X.F. Xu,Q. Li,A.Y. Dai,H.J. Zhou, J.X. Ling. Neoadjuvant chemotherapy followed by radical surgery for Stage IB2 cervical cancer in pregnancy. European Journal of Gynaecological Oncology. 2020. 41(3);489-491.

URL:

https://www.ejgo.net/articles/10.31083/j.ejgo.2020.03.5288

References

[1] Eibye S., Kjaer S.K., Mellemkjaer L.: “Incidence of pregnancy-associated cancer in Denmark, 1977-2006”. Obstet. Gynecol., 2013, 122, 608.

[2] Bigelow C.A., Horowitz N.S., Goodman A., Growdon W.B., Del Carmen M., Kaimal A.J.: “Management and outcome of cervical cancer diagnosed in pregnancy”. Am. J. Obstet. Gynecol., 2017, 216, 276.

[3] Islam S., Mukhopadhyay L., Howells R.: “Neo-adjuvant chemotherapy and radical surgery for stage 1B cervical cancer in pregnancy”. J. Obstet. Gynaecol., 2012, 32, 191.

[4] Dawood R., Instone M., Kehoe S.: “Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2013, 171, 205.

[5] Li J., Wang L., Zhang B., Peng Y., Lin Z.: “Neoadjuvant chemotherapy with paclitaxel plus platinum for invasive cervical cancer in pregnancy: two case report and literature review”. Arch. Gynecol. Obstet., 2011, 284, 779.

[6] Marnitz S., Köhler C., Oppelt P., Schmittel A., Favero G., Hasenbein K., et al.: “Cisplatin application in pregnancy: first in vivo analysis of 7 patients”. Oncology, 2010, 79, 72.

[7] Zagouri F., Sergentanis T.N., Chrysikos D., Bartsch R.: “Platinum derivatives during pregnancy in cervical cancer: a systematic review and metaanalysis”. Obstet. Gynecol., 2013, 121, 337.

[8] Zagouri F., Dimitrakakis C., Marinopoulos S., Tsigginou A., Dimopoulos M.A.: “Cancer in pregnancy: disentangling treatment modalities”. ESMO Open, 2016, 1, e000016.

[9] Azim H.A. Jr., Peccatori F.A., Pavlidis N.: “Treatment of the preg- nant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors”. Cancer Treat. Rev., 2010, 36, 101.

[10] Van Calsteren K., Verbesselt R., Ottevanger N., Halaska M., Heyns L., Van Bree R., et al.: “Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study”. Acta Obstet. Gynecol. Scand., 2010, 89, 1338.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top