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Neoadjuvant chemotherapy followed by radical surgery for Stage IB2 cervical cancer in pregnancy

  • X.F. Xu1
  • Q. Li1
  • A.Y. Dai1
  • H.J. Zhou1
  • J.X. Ling1,*,

1Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China

DOI: 10.31083/j.ejgo.2020.03.5288 Vol.41,Issue 3,June 2020 pp.489-491

Submitted: 17 June 2019 Accepted: 08 August 2019

Published: 15 June 2020

*Corresponding Author(s): J.X. Ling E-mail:


Background: Pregnancy with cervical cancer (CC) represents an important challenge. Case Report: The authors report a case of a 34-year old diagnosed with Stage IB2 squamous cell cervical cancer at 24+-week gestation who was then treated with neoadjuvant chemotherapy followed by cesarean section and radical hysterectomy with good outcome of both the mother and the baby. Conclusion: The results of this case study, combined with previous reports and the authors’ clincal experience, support the combination of paclitaxel and cisplatin for neoadjuvant chemotherapy when treating FIGO Stage IB2 cervical cancer in pregnancy.


Cancer; Carcinoma; Chemotherapy; Gynecological cancers; Mid-trimester pregnancy

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X.F. Xu,Q. Li,A.Y. Dai,H.J. Zhou, J.X. Ling. Neoadjuvant chemotherapy followed by radical surgery for Stage IB2 cervical cancer in pregnancy. European Journal of Gynaecological Oncology. 2020. 41(3);489-491.


[1] Eibye S., Kjaer S.K., Mellemkjaer L.: “Incidence of pregnancy-associated cancer in Denmark, 1977-2006”. Obstet. Gynecol., 2013, 122, 608.

[2] Bigelow C.A., Horowitz N.S., Goodman A., Growdon W.B., Del Carmen M., Kaimal A.J.: “Management and outcome of cervical cancer diagnosed in pregnancy”. Am. J. Obstet. Gynecol., 2017, 216, 276.

[3] Islam S., Mukhopadhyay L., Howells R.: “Neo-adjuvant chemotherapy and radical surgery for stage 1B cervical cancer in pregnancy”. J. Obstet. Gynaecol., 2012, 32, 191.

[4] Dawood R., Instone M., Kehoe S.: “Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2013, 171, 205.

[5] Li J., Wang L., Zhang B., Peng Y., Lin Z.: “Neoadjuvant chemotherapy with paclitaxel plus platinum for invasive cervical cancer in pregnancy: two case report and literature review”. Arch. Gynecol. Obstet., 2011, 284, 779.

[6] Marnitz S., Köhler C., Oppelt P., Schmittel A., Favero G., Hasenbein K., et al.: “Cisplatin application in pregnancy: first in vivo analysis of 7 patients”. Oncology, 2010, 79, 72.

[7] Zagouri F., Sergentanis T.N., Chrysikos D., Bartsch R.: “Platinum derivatives during pregnancy in cervical cancer: a systematic review and metaanalysis”. Obstet. Gynecol., 2013, 121, 337.

[8] Zagouri F., Dimitrakakis C., Marinopoulos S., Tsigginou A., Dimopoulos M.A.: “Cancer in pregnancy: disentangling treatment modalities”. ESMO Open, 2016, 1, e000016.

[9] Azim H.A. Jr., Peccatori F.A., Pavlidis N.: “Treatment of the preg- nant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors”. Cancer Treat. Rev., 2010, 36, 101.

[10] Van Calsteren K., Verbesselt R., Ottevanger N., Halaska M., Heyns L., Van Bree R., et al.: “Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study”. Acta Obstet. Gynecol. Scand., 2010, 89, 1338.

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