Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Treatment and survival outcomes from epithelial ovarian cancer in women aged 65 years or older
1Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University,230001, Hefei, China
2Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, China
3Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, China
4Organ Transplantation Center, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, China
DOI: 10.31083/j.ejgo.2020.03.5291 Vol.41,Issue 3,June 2020 pp.415-421
Submitted: 08 June 2019 Accepted: 05 September 2019
Published: 15 June 2020
*Corresponding Author(s): Ying Zhou E-mail: caddie1234@gmail.com
Objective: To describe the clinical features associated with the treatment and survival outcomes of older women with epithelial ovarian cancer. Materials and methods: Fifty-five women aged ≥ 65 years and diagnosed with epithelial ovarian cancer were enrolled. The clinical characteristics, treatment procedure and survival outcomes were presented and analyzed. Results: The mean age at the time of epithelial ovarian cancer diagnosis was 69.9 ± 3.9 years, with most women presenting with advanced stage disease (83.6%). Thirty-five patients (63.6%) received optimal cytoreduction, of whom 23 underwent surgery with a low surgical complexity score Forty-two percent of patients presented with postoperative complications, while five patients presented with three or more postoperative complications simultaneously. The large majority (87.3%) of patients received chemotherapy, and more than half (42%) relapsed. The three-year overall survival rate was 52.8%, while three-year progression-free survival was 33.3%. Advanced FIGO stage and residual lesions were the factors associated with reduced overall survival (p < 0.0001, p = 0.004), FIGO stage was also associated with progression-free survival (p = 0.001). Conclusions: Aggressive surgical debulking and chemotherapy are feasible for older epithelial ovarian cancer patients. Advanced FIGO stage and residual lesions are associated with reduced survival.
Geriatric patients; Epithelial ovarian cancer; Cytoreduction; Chemotherapy; Survival
Chenchen Zhu, Hanyuan Liu,Zhen Shen,Yanhu Xie,Tianjiao Zhang,Björn Nashan,Dabao Wu,Ying Zhou. Treatment and survival outcomes from epithelial ovarian cancer in women aged 65 years or older. European Journal of Gynaecological Oncology. 2020. 41(3);415-421.
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