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Original Research

Open Access

Sentinel lymph node mapping with carbon nanoparticles in endometrial cancer

  • J.Y. Chen1
  • Z.Q. Wang1
  • S.C. Liang1
  • H.Y. Hou1
  • D.B. Chen1
  • J.L. Wang1,*,

1Gynecology Department. Peking University people’s Hospital, Beijing, China

DOI: 10.31083/j.ejgo.2020.03.5312 Vol.41,Issue 3,June 2020 pp.408-414

Submitted: 30 June 2019 Accepted: 19 September 2019

Published: 15 June 2020

*Corresponding Author(s): J.L. Wang E-mail: wangjianliu@pku.edu.cn

Abstract

Aim: A retrospective study was conducted to explore the value of sentinel lymph node (SLN) mapping with carbon nanoparticles (CNP) in endometrial cancer patients. Methods: Seventy-six endometrial cancer patients who underwent sentinel lymph node mapping with or without systemic pelvic lymphadenectomy were involved in this study. All patients received cervical injection of carbon nanoparticles. The detection frequency for sentinel lymph nodes was calculated for all 76 patients, while the sensitivity and negative predictive value for metastasis were calculated for patients who underwent additional systemic pelvic lymphadenectomy (n=43). Clinical factors associated with sentinel lymph node detection were also evaluated. Results: The overall and bilateral detection frequencies were 71.1% (54/76) and 61.1% (33/54), respectively. A total of 291 sentinel lymph nodes were removed from 54 patients, with the median number removed per patient being 4 (range 3-7). sentinel lymph nodes were mostly located in the external lilac (45.7%) and obturator (41.2%) regions. Fifteen positive lymph nodes including 6 positive sentinel lymph nodes were found in 5 patients. Two of the five patients failed sentinel lymph node mapping but showed positive lymph nodes after systemic pelvic lymphadenectomy. The sensitivity and negative predictive value of sentinel lymph node mapping were therefore both 100%. Conclusion: The detection frequency of sentinel lymph node mapping with carbon nanoparticles in endometrial cancer patients was not as high as for some other cancer types. However, the accuracy of this method was high despite the relatively low detection frequency. More research is needed to improve sentinel lymph node mapping in endometrial cancer patients.

Keywords

Sentinel lymph node; Endometrial cancer; Carbon nanoparticles

Cite and Share

J.Y. Chen,Z.Q. Wang,S.C. Liang,H.Y. Hou, D.B. Chen,J.L. Wang. Sentinel lymph node mapping with carbon nanoparticles in endometrial cancer. European Journal of Gynaecological Oncology. 2020. 41(3);408-414.

References

[1] Wakayama A., Kudaka W., Matsumoto H., Aoyama H., Ooyama T., Taira Y., et al.: “Lymphatic vessel involvement is predictive for lymph node metastasis and an important prognostic factor in endometrial cancer”. Int. J. Clin. Oncol., 2018, 23, 532.

[2] Vargas R., Rauh-Hain J.A., Clemmer J., Clark R.M., Goodman A., Growdon W.B., et al.: “Tumor size, depth of invasion, and histologic grade as prognostic factors of lymph node involvement in endometrial cancer: a SEER analysis”. Gynecol. Oncol., 2014, 133, 216.

[3] Yost K.J., Cheville A.L., Al-Hilli M.M., Mariani A., Barrette B.A., McGree M.E., et al.: “Lymphedema after surgery for endometrial cancer: prevalence, risk factors, and quality of life”. Obstet. Gynecol., 2014, 124, 307.

[4] Ruscito I., Gasparri M.L., Braicu E.I., Bellati F., Raio L., Sehouli J., et al.: “Sentinel Node Mapping in Cervical and Endometrial Cancer: Indocyanine Green Versus Other Conventional Dyes-A Meta-Analysis”. Ann. Surg. Oncol., 2016, 23, 3749.

[5] NCCN Guidelines Version. 2. 2017: “Uterine Neoplasms”. Available at: http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf

[6] NCCN Guidelines Version 2. 2015: “Uterine Neoplasms”. Available at: http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf.

[7] Pecorelli S.: “Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium”. Int. J. Gynaecol. Obstet., 2009, 105, 103.

[8] Kang S., Yoo H.J., Hwang J.H., Lim M.C., Seo S.S., Park S.Y.: “Sentinel lymph node biopsy in endometrial cancer: meta-analysis of 26 studies”. Gynecol. Oncol., 2011, 123, 522.

[9] How J.A., O’Farrell P., Amajoud Z., Lau S., Salvador S., How E., et al.: “Sentinel lymph node mapping in endometrial cancer: a system- atic review and meta-analysis”. Minerva Ginecol., 2018, 70, 194.

[10] Geppert B., Lonnerfors C., Bollino M., Arechvo A., Persson J.: “A study on uterine lymphatic anatomy for standardization of pelvic sentinel lymph node detection in endometrial cancer”. Gynecol. On- col., 2017, 145, 256.

[11] Gargiulo T., Giusti M., Bottero A., Leo L., Brokaj L., Armellino F., et al.: “Sentinel Lymph Node (SLN) laparoscopic assessment early stage in endometrial cancer”. Minerva Ginecol., 2003, 55, 259.

[12] Sawicki S., Lass P., Wydra D.: “Sentinel Lymph Node Biopsy in Endometrial Cancer–Comparison of 2 Detection Methods”. Int. J. Gynecol. Cancer, 2015, 25, 1044.

[13] Sahbai S., Taran F.A., Fiz F., Staebler A., Becker S., Solomayer E., et al.: “Pericervical Injection of 99mTc-Nanocolloid Is Supe- rior to Peritumoral Injection for Sentinel Lymph Node Detection of Endometrial Cancer in SPECT/CT”. Clin. Nuclear Med., 2016, 41, 927.

[14] Abu-Rustum N.R., Gomez J.D., Alektiar K.M., Solow R.A., Hens- ley M.L., Leitao M.M. Jr., et al.: “The incidence of isolated paraaortic nodal metastasis in surgically staged endometrial cancer patients with negative pelvic lymph nodes”. Gynecol. Oncol., 2009, 115, 236.

[15] Papadia A., Zapardiel I., Bussi B., Ghezzi F., Ceccaroni M., De Ponti E., et al.: “Sentinel lymph node mapping in patients with stage I endometrial carcinoma: a focus on bilateral mapping identification by comparing radiotracer Tc99(m) with blue dye versus indocyanine green fluorescent dye”. J. Cancer Res.Clinical Oncol., 2017, 143, 475.

[16] Miyashiro I., Hiratsuka M., Sasako M., Sano T., Mizusawa J., Naka- mura K., et al.: “High false-negative proportion of intraoperative histological examination as a serious problem for clinical applica- tion of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302”. Gastric cancer, 2014, 17, 316.

[17] Lu Y., Wei J.Y., Yao D.S., Pan Z.M., Yao Y.: “Application of carbon nanoparticles in laparoscopic sentinel lymph node detection in patients with early-stage cervical cancer”. PLoS One, 2017, 12, e0183834.

[18] Liang S.C., Wang Z.Q., Wang J.L.: “Clinical analysis of 76 cases of sentinel lymph node detection in cervical cancer and endometrial cancer”. Zhonghua Fu Chan Ke Za Zhi, 2017, 52, 605.

[19] Eitan R., Sabah G., Krissi H., Raban O., Ben-Haroush A., Gold- schmit C., et al. Robotic blue-dye sentinel lymph node detection for endometrial cancer - Factors predicting successful mapping”. Eur. J. Surg. Oncol., 2015, 41, 1659.

[20] Colombo N., Preti E., Landoni F., Carinelli S., Colombo A., Marini C., et al.: “Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up”. Ann. Oncol., 2013, 24, vi33.

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