Demodex folliculorum mite infestation in gynecological cancers: A case control study

Objective: To determine the frequency of Demodex (D.) folliculorum infestation in patients with gynecological cancer. Materials and Methods: This cross-sectional study was conducted between January 2015 and May 2015. Eighty-seven patients with gynecologic cancer and ninety control subjects were included and the patients characterics were recorded. Demodex was detected by standardized skin surface biopsy for skin lesions. Results: No statistically significant difference was found between the groups in terms of age, diabetes mellitus, body mass index (BMI), hypertension, and the use of radiotherapy and chemotherapy. D. folliculorum infestation was increased in the patient group (47.1%) when compared to the control group (8.9%) (p < 0.001). The frequency of D. folliculorum was higher in the cancer groups and particularly in ovarian cancer (58.7%). Conclusions: Patients with gynecological cancers are at risk for D. folliculorum mite infestation and this is explained by the immunosuppressed condition of the patients due to the cancer.

Gynecological cancer; Demodex folliculorum

[1] Suh D.H., Lee K.H., Kim K., Kang S., Kim J.W.: “Major clinical research advances in gynecologic cancer in 2014”. J Gynecol Oncol. 2015, 26, 156­167.

[2] Yang L., Carbone D.P.: “Tumor­Host Immune Interactions and Den­ tritic Cell Dysfunction”. Adv Cancer Res., 2004, 92, 13­27.

[3] Unat E.K., Yucel A., Atlas K., Samastı M., Editors. “Unatin Tip Parazitolojisi” 5. Baski Cerr Tip Fak. Vakfı Yay., 15, 1995.

[4] Gerber P.A., Kukova G., Buhren B.A., Homey B.: “Density of De­ modex folliculorum in patients receiving epidermal growth factor receptor inhibitors”. Dermatology., 2011, 222, 144­147.

[5] Patrizi A., Neri I., Chieregato C., Misciali M.: “Demodicidosis in immunocompetent young children: report of eight cases”. Derma­ tology., 1997, 195, 239­242.

[6] Damian D., Rogers M.: “Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin”. Int J Der­ matol., 2003, 42, 724­726.

[7] Akilov O.E., Mumcuoglu K.Y.: “Immune response in demodico­ sis”. J Eur Acad Dermatol Venereol., 2004, 18, 440­444.

[8] Sheals J.G.: “Arachnida. Smith KGV ed. Insects and Another Arthropods of Medical Importance”. London: The Trustees of the British Museum (Natural History), 1973, 17.

[9] Varma M.G.R.: “Ticks and Mites”. Manson­Bahr PEC ed. Manson’s Tropical Diseases 20 th. Ed. W.B. Saunders Com., 1996, 1649.

[10] Erbagci Z, Erbagci I, Erkiliç S.: “High incidence of demodicidosis in eyelid basal cell carcinomas”. Int J Dermatol., 2003, 42, 567­571.

[11] Sun J., Gui X., He J., Liu H.M., Yu H.Y., Xia C.Y., et al.: “The rela­ tionship between infestation of Demodex folliculorum and epider­ mal neoplasm on face”. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi., 2005, 23, 428­431.

[12] Talghini S., Fouladi D.F., Babaeinejad S., Shenasi R., Samani S.M.: “Demodex mite, rosacea and skin melanoma; coincidence or asso­ ciation?” Turkiye Parazitol Derg., 2015, 39, 41­46.

[13] Seyhan M.E., Karincaoglu Y., Bayram N., Aycan O., Kuku I.: “Den­ sity of Demodex folliculorum in haematological malignancies”. J Int Med Res., 2004, 32, 411­415.

[14] Olt S., Yalçın G.G., Uysal O.S., Karakeçe E., Ciftci I.H., “Demodex spp. Infestation in a breast­cancer patient: A case report”. Niger Med J., 2013, 54, 349­350.

[15] Inci M., Kaya O.A., Yula E., Gokce H., Rifaioglu M.M., Demir­ tas O., et al.: “Investigating Demodex folliculorum in patients with urological cancer”. Turkish Soc Parasitol., 2012, 36, 208­210.

[16] Castanet J., Monpoux F., Mariani R., Ortonne J.P., Lacour J.P.: “De­ modicidosis in an immunodeficient child”. Pediatr Dermatol., 1997, 14, 219­220.

[17] Sönmez Ö.U., Yalçın Z.G., Karakeçe E., Çiftci İ.H., Erdem T.: “As­ sociations between Demodex species infestation and various types of cancer”. Acta Parasitol., 2013, 58, 551­555.

[18] Aydingöz I.E., Dervent B.: “Demodex folliculorum in renal trans­ plant patients revisited”. Dermatology., 2001, 203, 272­273.

[19] Xie J., Kvaskoff M., Li Y., Zhang M., Qureshi A.A., Missmer S.A., et al.: “Severe teenage acne and risk of endometriosis”. Hum Re­ prod., 2014, 29, 2592­2599.

[20] Sato S., Wakisaka T., Hamazaki Y., Oikawa N., Toki T., Yamauchi R., et al. “Serum levels of immunosuppressive acidic protein in gy­ necological cancer”. Gan No Rinsho., 1983, 29, 897­899.

[21] Conrad C., Gregorio J., Wang Y.H., Ito T., Meller S., Hanabuchi S., et al.: “Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T­regulatory cells”. Cancer Res., 2012, 72, 5240­5249.