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Collision tumour of endometrial stromal sarcoma, uterine tumour resembling ovarian sex-cord tumour, and leiomyoma

  • Chiharu Mizoguchi1,*,
  • Harunobu Matsumoto1
  • Kaei Nasu1,2
  • Kentaro Kai1,3
  • Motoki Arakane4
  • Hisashi Narahara1

1Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan

2Division of Obstetrics and Gynecology, Support System for Community Medicine, Faculty of Medicine, Oita University, Oita, Japan

3Department of Obstetrics and Gynecology, Nakatsu Municipal Hospital, Oita, Japan

4Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan

DOI: 10.31083/j.ejgo.2020.04.3936 Vol.41,Issue 4,August 2020 pp.634-637

Submitted: 30 July 2016 Accepted: 24 October 2019

Published: 15 August 2020

*Corresponding Author(s): Chiharu Mizoguchi E-mail: cmizoguchi@oita-u.ac.jp

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Abstract

Purpose of investigation: Endometrial stromal (ES) tumours may show different types of differentiation including smooth muscle and sex-cord like elements. A common problem is the differential diagnosis of ES tumour variants from other tumours that have smooth muscle or sex cord-like elements. We report a case of collision tumour that was composed of a low-grade endometrial stromal sarcoma (ESS) with sex-cord like differentiation, a uterine tumour resembling ovarian sex-cord tumour (UTROSCT), and a leiomyoma. Result: The patient was a 63-year-old multiparous woman who was referred to us with the complaint of recurrent abnormal uterine bleeding. Magnetic resonance imaging demonstrated a 3.4-cm-dia. solid tumour in her uterine cavity. We performed an abdominal total hysterectomy and a bilateral salpingo-oophorectomy. On gross and microscopic examination, the tumour consisted of a CD10-positive low-grade ESS, a CD10-negative UTROSCT, and a leiomyoma. Conclusion: ESS should be distinguished from UTROSCT and leiomyoma because of its malignant potential.

Keywords

Endometrial stromal sarcoma; Leiomyoma; Sexcord differentiation; Uterine neoplasm; uterine tumour resembling ovarian

sexcord tumour

Cite and Share

Chiharu Mizoguchi, Harunobu Matsumoto, Kaei Nasu, Kentaro Kai, Motoki Arakane, Hisashi Narahara. Collision tumour of endometrial stromal sarcoma, uterine tumour resembling ovarian sex-cord tumour, and leiomyoma. European Journal of Gynaecological Oncology. 2020; 41(4): 634-637. doi: 10.31083/j.ejgo.2020.04.3936

URL:

https://www.ejgo.net/articles/10.31083/j.ejgo.2020.04.3936

References

[1] Xue W.C., Cheung A.N.: ”Endometrial stromal sarcoma of uterus”. Best Pract Res Clin Obstet Gynaecol. 2011, 25, 719.

[2] Munro M.G., Critchley H.O., Fraser I.S., Group F.M.D.W.: ”The FIGO classification of causes of abnormal uterine bleeding in the reproductive years”. Fertil Steril. 2011, 95, P2204.

[3] Oliva E., Clement P.B., Young R.H., Scully R.E.: ”Mixed endome­trial stromal and smooth muscle tumors of the uterus: a clinico­pathologic study of 15 cases”. Am J Surg Pathol. 1998, 22, 997.

[4] Clement P.B., Scully R.E.: ”Uterine tumors resembling ovarian sex­cord tumors. A clinicopathologic analysis of fourteen cases”. Am J Clin Pathol. 1976, 66, 512­25.

[5] Dionigi A., Oliva E., Clement P.B., Young R.H.: ”Endometrial stro­ mal nodules and endometrial stromal tumors with limited infiltra­tion: a clinicopathologic study of 50 cases”. Am J Surg Pathol. 2002, 26, 567.

[6] Feng W., Hua K., Gudlaugsson E., Yu Y., Zhou X., Baak J.P.: ”Prog­nostic indicators in WHO 2003 low­grade endometrial stromal sar­coma”. Histopathology. 2013, 62, 675.

[7] Chang K.L., Crabtree G.S., Lim­Tan S.K., Kempson R.L., Hen­drickson M.R.: ”Primary uterine endometrial stromal neoplasms. A clinicopathologic study of 117 cases”. Am J Surg Pathol. 1990, 14, 415.

[8] Kuman R.J., Carcangui M.L., Herrington C.S., Young R.H. Mes­-enchymal tumours. In: WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon, France: International Agency for Research on Cancer; 2014.

[9] Umeda S., Tateno M., Miyagi E., Sakurai K., Tanaka R., Tateishi Y., et al.: ”Uterine tumors resembling ovarian sex cord tumors (UTROSCT) with metastasis: clinicopathological study of two cases”. Int J Clin Exp Pathol. 2014, 7, 1051.

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