Article Data

  • Views 546
  • Dowloads 153

Original Research

Open Access

Safety and efficacy of fertility-sparing surgery for an orthotopic xenograft model of epithelial ovarian cancer in nude mice

  • Gen-Hai Zhu1,*,
  • Kang Wang1
  • Lan Hong1
  • Xin-Hui Fu2
  • Fu-Jin Liu3
  • Hai-Yan Huang4

1 Department of Gynecology, Hainan General Hospital, Haikou 570311, P. R. China

2Hainan Drug Research Institute, Haikou 570311, P. R. China

3Department of Pathology, Hainan General Hospital, Haikou 570311, P. R. China

4Medical Research Center, Hainan General Hospital, Haikou 570311, P. R. China

DOI: 10.31083/j.ejgo.2020.04.5204 Vol.41,Issue 4,August 2020 pp.609-616

Submitted: 29 October 2018 Accepted: 21 January 2019

Published: 15 August 2020

*Corresponding Author(s): Gen-Hai Zhu E-mail: genhaizhu@163.com

Abstract

Objective: To analyze the safety of, and factors influencing, fertility-sparing surgery in nude a mouse model bearing an orthotopic xenograft of human epithelial ovarian cancer. Materials and Methods: Eight weeks post-xenograft transplantation, mice were split into five cohorts for different fertility-sparing surgeries to remove their tumours. All cohorts were observed for three months to analyse the effectiveness of the different surgical methods in terms of impact on occult cancer detection in the remaining ovarian tissues, and the effect of invasion types on the recurrence rate of ovarian tumor. Results: No obvious difference was found in the recurrence rate in groups subject to unilateral adnexectomy or ovarian-sparing local mass excision, when compared to the hysterectomy-bilateral adnexectomy group. The recurrence rate of tumors with pseudocapsule penetration and/or tumor dissection was higher than that with other invasion types and other surgery. The frequency of occult cancer detection in cancers displaying pseudocapsule and pseudocapsule invasion was significantly higher in those with tumor dissection when compared to those with ovarian-sparing local mass excision. Conclusions: Fertility-sparing surgery is not a factor influencing the prognosis of bilateral epithelial ovarian cancer. However, the invasion type of ovarian tumor exhibits an important role in fertility-sparing surgery; with tumors with pseudocapsule or pseudocapsule invasion being suitable for surgery, whereas tumors appearing with pseudocapsule penetration should be not be considered for this surgery. Ovarian-sparing local mass excision as a fertility-sparing surgery is safe and feasible for epithelial ovarian cancer at the experimental level, and now demands further pre-clinical validation in multi-center trials.

Keywords

Epithelial ovarian cancer; Fertility-sparing surgery; Neoplasm invasion type; Ovarian-sparing local mass excision

Cite and Share

Gen-Hai Zhu,Kang Wang,Lan Hong,Xin-Hui Fu,Fu-Jin Liu,Hai-Yan Huang. Safety and efficacy of fertility-sparing surgery for an orthotopic xenograft model of epithelial ovarian cancer in nude mice. European Journal of Gynaecological Oncology. 2020. 41(4);609-616.

References

[1] Beckmann MW, Dittrich R, Lotz L, van der Ven K, van der Ven H.H., et al.: “Fertility protection: complications of surgery and results of removal and transplantation of ovarian tissue”. Reprod. Biomed. Online, 2018, 36, 188.

[2] Smith K.L., Gracia C., Sokalska A., Moore H.: “Advances in Fertility Preservation for Young Women With Cancer”. Am. Soc. Clin. Oncol. Educ. Book, 2018, 23, 27.

[3] Kim S., Lee Y., Lee S., Kim T.: “Ovarian tissue cryopreservation and transplantation in patients with cancer”. Obstet. Gynecol. Sci., 2018, 61, 431.

[4] Zhu G.H., Wang S.T., Yao M.Z., Cai J.H., Chen C.Y., Yang Z.X.: “Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice”. Genet. Mol. Res., 2014, 13, 2978.

[5] Zhu G.H., Wang S.T., Yang Z.X., Cai J.H., Chen C.Y., Yao M.Z.: “Safety assessment of ovarian cryopreservation and transplantation in nude mice bearing human epithelial ovarian cancer”. Asian Pac. J. Cancer Prev., 2012, 13, 4669.

[6] Yilmaz E., Gul M., Melekoglu R., Koleli I.: “Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors”. Acta Cir. Bras., 2018, 33, 641.

[7] Kim K., Zang R., Choi S.C., Ryu S.Y., Kim J.W.: “Current status of gynecological cancer in China”. J. Gynecol. Oncol., 2009, 20, 72.

[8] Armstrong D.K.: “New Therapies for Ovarian Cancer”. J. Natl. Compr. Canc. Netw., 2018, 16, 632.

[9] Moss J.L., Murphy J., Filiaci V.L., Wenzel L.B., Minasian L., Temkin S.M.: “Disparities in health-related quality of life in women undergoing treatment for advanced ovarian cancer: the role of individual-level and contextual social determinants”. Support Care Cancer, 2019, 27, 531.

[10] Miller D.M., Ehlen T.G., Saleh E.A.: “Successful term pregnancy following conservative debulking surgery for a stage IIIA serous low-malignant-potential tumor of the ovary: a case report”. Gy- necol. Oncol., 1997, 66, 535.

[11] Merrill R.M., Anderson A.E., Merrill J.G.: “Racial/ethnic differences in the use of surgery for ovarian cancer in the United States”. Adv. Med. Sci., 2010, 55, 93.

[12] Lou T., Yuan F., Feng Y., Wang S., Bai H., Zhang Z.: “The safety of fertility and ipsilateral ovary procedures for borderline ovarian tumors”. Oncotarget, 2017, 8, 115718.

[13] Bentivegna E., Gouy S., Maulard A., Pautier P., Leary A., Colombo N., Morice P.: “Fertility-sparing surgery in epithelial ovarian cancer: a systematic review of oncological issues”. Ann. Oncol., 2016, 27, 1994.

[14] Cho Y.J., Lee H.S., Kim J.M., Lee S.Y., Song T., Seong S.J., Kim M.L.: “Ovarian-sparing local mass excision for ovarian fibroma/fibrothecoma in premenopausal women”. Eur. J. Obstet. Gy- necol. Reprod. Biol., 2015, 185, 78.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top