Article Data

  • Views 774
  • Dowloads 149

Case Reports

Open Access

Recurrent immature teratoma in a 47 year old with maturation in subsequent laparotomies and a grave course

  • Sarita Kumari1,*,
  • Jai Bhagwan Sharma2

1Sarita Kumari, All India Institute of Medical Sciences, New Delhi, pin-110029, India

2Jai Bhagwan Sharma, Dept of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, pin-110029, India

DOI: 10.31083/j.ejgo.2020.05.5330 Vol.41,Issue 5,October 2020 pp.813-816

Submitted: 01 August 2019 Accepted: 14 January 2020

Published: 15 October 2020

*Corresponding Author(s): Sarita Kumari E-mail: sarita2325@gmail.com

Abstract

Ovarian immature teratoma (IT) is uncommon after the first two decades of life. Management is largely surgical, and recurrences are rare. Ovarian IT has the potential to convert into mature disease at the time of recurrence. The current case report describes a 47-year-old female patient who developed two recurrences within three years. The primary disease and first recurrence were managed surgically, whereas the second recurrence was managed surgically plus adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) regimen. Histopathology was immature teratoma grade 3 initially which progressed to immature teratoma grade 1 in last recurrence. Alphafeto protein levels were never raised except two months after the last laparotomy when the patient was diagnosed to have hepatic metastases and succumbed to disease. Prognosis was grave in our patient. Advanced age may be a one contributing factor. Relapse of ovarian IT is uncommon and its optimal management remains debatable.


Keywords

Recurrent immature teratoma; Ovarian; Surgery.


Cite and Share

Sarita Kumari,Jai Bhagwan Sharma. Recurrent immature teratoma in a 47 year old with maturation in subsequent laparotomies and a grave course. European Journal of Gynaecological Oncology. 2020. 41(5);813-816.

References

[1] Quirk J.T., Natarajan N.: “Ovarian cancer incidence in the United States, 1992-1999”. Gynecol. Oncol., 2005, 97, 519.

[2] Luczak J., Baglaj M.: “Ovarian teratoma in children: a plea for col-laborative clinical study”. J. Ovarian. Res., 2018, 11, 75.

[3] Barbosa L.C., Francisco A.M., Archangelo Sde.C., Soares F.C., Ferreira M.C., Maia R.L.: “Bilateral immature ovarian teratoma in a12-year old girl: case report”. Rev. Assoc. Med. Bras., 2012, 58, 138.

[4] Billmire D., Vinocur C., Rescorla F., Cushing B., London W., Schlatter M., et al.: “Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study”. J. Pediatr. Surg., 2004, 39, 424.

[5] Gershenson D.M.: “Management of ovarian germ cell tumors”. J. Clin. Oncol., 2007, 25, 2938.

[6] Jeffery G.M., Theaker J.M., Lee A.H.S., Blaquiere R.M., Smart C.J., Mead G.M., et al.: “The growing teratoma syndrome”. Br. J. Urol., 1991, 67, 195.

[7] Mrabti H., El Ghissassi J., Sbitti Y., Amrani M., Hachi H., Errihani H.: “Growing teratoma syndrome and peritoneal gliomatosis”. Case Rep. Med., 2011, 2011, 123527.

[8] Shibata K., Kajiyama H., Kikkawa F.: “Growing teratoma syndrome of the ovary showing three patterns of metastasis: a case report”. Case Rep. Oncol., 2013, 6, 544.

[9] Kampan N., Irianta T., Djuana A., Shan L.P., Omar H., Dali A.: “Growing teratoma syndrome: a rare case report and review of the literature”. Case Rep. Obstet. Gynecol., 2012, 2012, 134032.

[10] Logothetis C.J., Samuels M.L., Trindade A., Johnson D.E.: “The growing teratoma syndrome”. Cancer., 1982, 50, 1629.

[11] Li X., Zhu D., Lv L.I., Yu J.: “ An uncommon recurrence of an immature teratoma: a case report”. Oncol. Lett., 2016, 11, 2453.

[12] Pashankar F., Hale J.P., Dang H., Krailo M., Brady W.E., Rodriguez-Galindo C., et al.: “Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative”. Cancer., 2016, 122, 230.

[13] Cushing B., Giller R., Ablin A., Cohen L., Cullen J., Hawkins E., et al.: “Surgical resection alone is effective treatment for ovarian immature teratoma in children and adolescents: a report of the pediatric oncology group and the children’s cancer group”. Am. J. Obstet.Gynecol., 1999, 181, 353.

[14] Newton C., Murali K., Ahmad A., Hockings H., Graham R., Lib-erale V., et al.: “A multicentre retrospective cohort study of ovarian germ cell tumours: evidence for chemotherapy de-escalation and alignment of paediatric and adult practice”. Eur. J. Cancer., 2019, 113, 19.

[15] O’Connor D.M., Norris H.J.: “The influence of grade on the outcome of stage I ovarian immature (malignant) teratomas and the reproducibility of grading”. Int. J. Gynecol. Pathol., 1994, 13, 283.

[16] Pectasides D., Pectasides E., Kassanos D.: “Germ cell tumors of the ovary”. Cancer. Treat. Rev., 2008, 34, 427.

[17] Mann J.R., Gray E.S., Thornton C., Raafat F., Robinson K., Collins G. S., et al.: “Mature and immature extracranial teratomas in children: the UK Children’s Cancer Study Group Experience”. J. Clin. Oncol., 2008, 26, 3590.

[18] Zagame L., Pautier P., Duvillard P., Castaigne D., Patte C., LhommeC.: “Growing teratoma syndrome after ovarian germ cell tumors”. Obstet. Gynecol., 2006, 108, 509.

[19] Gorbatiy V., Spiess P.E., Pisters L.L.: “The growing teratoma syndrome: current review of the literature”. Indian. J. Urol., 2009, 25, 186.

[20] Li S., Liu Z., Dong C., Long F., Liu Q., Sun D., et al.: “Growing teratoma syndrome secondary to ovarian giant immature teratoma in an adolescent girl”. Medicine (Baltimore)., 2016, 18, 95.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top