Utility of colposcopy in the management of ASCUS and LSIL in women younger than 25-year-old: A retrospective multicenter study
1Health Science University, Haseki Teaching and Research Hospital, Department of Gynecology, 34130, Istanbul, Turkey
2Health Science University, Zeynep Kamil Training and Research Hospital, Department of Gynecologic Oncology, 34668, Istanbul, Turkey
3Health Science University, Bakirkoy Sadi Konuk Training and Research Hospital,
4Department of Gynecologic Oncology, 34147, Istanbul, Turkey
5Health Science University Taksim Gaziosmanpasa Training and Research Hospital, Department of Gynecology, 34255, Istanbul, Turkey
DOI: 10.31083/j.ejgo.2020.05.5405 Vol.41,Issue 5,October 2020 pp.685-688
Submitted: 17 October 2019 Accepted: 24 March 2020
Published: 15 October 2020
Objective: We aimed to analyze the colposcopy-guided biopsy results in women aged 21-24 years with clinical suspicion for cervical lesion and/or cytological abnormality. Methods: This was a retrospective cohort study conducted on 461 patients undergoing colposcopic examination and biopsy between the ages of 21-24. The colposcopy-guided biopsy results of women with atypical squamous cells of undetermined significance (atypical squamous cells of undetermined significance) cytology were cervical intraepithelial neoplasia (cervical intraepithelial neoplasia) 2 in 9 patients and cervical intraepithelial neoplasia 3 in 5 patients. Results: The colposcopy-guided biopsy results of women with low-grade squamous intraepithelial lesion (low-grade squamous intraepithelial lesion) cytology were cer-vical intraepithelial neoplasia 2 in 17 patients, cervical intraepithelial neoplasia 3 in 10 patients, and invasive cancer in 1 patient. One of the high-grade squamous intraepithelial lesion (high-grade squamous intraepithelial lesion) patients had invasive cervical cancer. The cytology results of women with cervical intraepithelial neoplasia 1 after 6 months from colposcopy-guided biopsy were atypical squamous cells of undetermined significance (n = 11), and low-grade squamous intraepithelial lesion (n = 6). The cytology results of women with cervical intraepithelial neoplasia 1 after 12 months were atypical squamous cells of undetermined significance in 2 women, and low-grade squamous intraepithelial lesion in 2 women. The cytology results after 12 months from colposcopy-guided biopsy were high-grade squamous intraepithelial lesion in 16 of 433 women who underwent follow-up (3.7%). There were no significant statistically differences between cervical intraepithelial neoplasia 2 patients with and without treatment in terms of cytology results at 6 months (p = 1.00). However, there were significant statistically differences between cervical intraepithelial neoplasia 2 patients with and without treatment in terms of cytology results at 12 months (p= 0.042). Conclusions: Colposcopic examination should perform in women aged 21-24 years with atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion due to the possibility of high-grade squamous intraepithelial lesion and invasive cancer.
Cervical intraepithelial neoplasia; Colposcopy; Human papillomavirus.
Behiye Pinar Goksedef,Burak Giray,Canan Kabaca,Murat Ekmez,Sinan Gulec,Esra Keles,Isa Aykut Ozdemir,Suleyman Salman,Derya Sivri Aydin. Utility of colposcopy in the management of ASCUS and LSIL in women younger than 25-year-old: A retrospective multicenter study. European Journal of Gynaecological Oncology. 2020. 41(5);685-688.
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