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Secondary small cell vaginal cancer after operative therapy for endometrial cancer

  • Ikuji Shimazaki1
  • Yasunori Hashiguchi1,*,
  • Makoto Yamauchi1
  • Mari Kasai1
  • Takeshi Fukuda1
  • Tomoyuki Ichimura1
  • Tomoyo Yasui1
  • Toshiyuki Sumi1

1Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Japan

DOI: 10.31083/j.ejgo.2020.05.5429 Vol.41,Issue 5,October 2020 pp.821-823

Submitted: 08 November 2018 Accepted: 06 May 2020

Published: 15 October 2020

*Corresponding Author(s): Yasunori Hashiguchi E-mail: Yasunori Hashiguchi

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Abstract

Background: Gynecologic neuroendocrine carcinoma is rare. There is no case report of secondary small cell vaginal cancer after operative therapy for endometrial cancer. Case: A 51 year-old patient was treated by operative therapy for endometrial cancer stage IA (pT1aN0M0). After 9 months’ post-treatment, the patient visited the hospital with abnormal bleeding, and a necrotic lesion in the left upper third of the posterior vaginal wall was detected near the vaginal cut edge. Biopsy of this tumor revealed neuroendocrine carcinoma, the patient was diagnosed with small cell carcinoma of the vagina stage I (pT1NXM0) by following operative resection. The patient received chemotherapy with irinotecan and cisplatin. After eleven months of follow-up, the patient remains alive without recurrence. Conclusion: In case of small cell vaginal cancer, chemotherapy regimen with irinotecan and cisplatin should be considered as a therapeutic option.


Keywords

Secondary vaginal cancer; Small cell carcinoma; Endometrial cancer.


Cite and Share

Ikuji Shimazaki,Yasunori Hashiguchi,Makoto Yamauchi,Mari Kasai,Takeshi Fukuda,Tomoyuki Ichimura,Tomoyo Yasui,Toshiyuki Sumi. Secondary small cell vaginal cancer after operative therapy for endometrial cancer. European Journal of Gynaecological Oncology. 2020. 41(5);821-823.

URL:

https://www.ejgo.net/articles/10.31083/j.ejgo.2020.05.5429

References

[1] Bing Z., Levine L., Lucci J.A., Hatch S.S., Eltorky M.A.: “Primarysmall cell neuroendocrine carcinoma of the vagina: A clinicopathologic study”. Arch Pathol Lab Med, 2004, 128, 857-862.

[2] Bhalodia J.N., Kapapura D.V., Parekh M.N.: “Primary small cell neuroendocrine carcinoma of the vagina: a rare case report”. Pathol Res Intt, 2011, e306921.

[3] Oliveira R., Bócoli M.C., Saldanha J.C., Murta E.F.C. and Nomelini R. S.: “Primary Small Cell Carcinoma of the Vagina”. Case Reports in Obstetrics and Gynecology, 2013, 2013, 1-4.

[4] Yan W.X., Jia X.J., Chen Y.B., Zhao Z.X., Liu X.L., Yang J.Z., Wang T. J.: “Primary small cell carcinoma of the vagina with pulmonary metastasis: a case report”. Eur J Gynaecol oncol, 2016, 37, 129-132.

[5] Kombathula S.H., Rapole P.S., Prem S.S. and Badhe B.: “Primary small cell carcinoma of the vagina: a rare instance of prolonged survival”. Bmj Case Reports, 2019, 12, e227100.

[6] Tamura R., Yokoyama Y., Kobayashi A., Osawa Y., Shigeto T., Fu-tagami M., et al.: “A Case of Small Cell Carcinoma of the Vagina”. Rare Tumors, 2013, 5, 189-191.

[7] Noda K., Nishiwaki Y., Kawahara M., Negoro S., Sugiura T., Yokoyama A., et al.: “Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer”. N. Engl. J. Med., 2002, 346, 85-91.


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