Article Data

  • Views 640
  • Dowloads 103

Case Reports

Open Access

Mullerian adenosarcoma of the uterine cervix misdiagnosed as an endocervical polyp on magnetic resonance imaging and two preoperative consecutive biopsies: A diagnostic challenge

  • Eun Hee Yu1,†
  • Yong Jung Song1,†
  • Seul Yi Lee1
  • Seo Yoon Hwang1
  • Nam Kyung Lee2
  • Kyung Un Choi3
  • Dong Soo Suh1,4
  • Ki Hyung Kim1,4,*,

1Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan 49241, Republic of Korea

2Department of Radiology, Pusan National University School of Medicine, Busan 49241, Republic of Korea

3Department of Pathology, Pusan National University School of Medicine, Busan 49241, Republic of Korea

4Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea

DOI: 10.31083/j.ejgo.2020.06.2095 Vol.41,Issue 6,December 2020 pp.1045-1049

Submitted: 22 March 2019 Accepted: 18 June 2019

Published: 15 December 2020

*Corresponding Author(s): Ki Hyung Kim E-mail: ghkim@pusan.ac.kr

† These authors contributed equally.

Abstract

Mullerian adenosarcoma of the uterine cervix generally displays cervical polyps and can be often misdiagnosed as benign endocervical polyps both clinically and pathologically. A 52-year-old woman presented with a two-month history of postmenopausal bleeding. Pelvic examination revealed a large polyp-like mass protruding from the cervical ostium. Two preoperative consecutive biopsies showed a histologic diagnosis consistent with an endocervical polyp. Pelvic magnetic resonance imaging (MRI) depicted a lobulated well- en-hancing endocervical mass, suggestive of an endocervical polyp based on the apparent diffusion coefficient (ADC) value. The patient was subjected to total hysterectomy with bilateral salpingectomy. Microscopically, the tumor was composed of epithelial and stromal components. The final pathologic diagnosis was Mullerian adenosarcoma of the cervix. The authors presented an unusual case that demonstrated an endocervical polyp on magnetic resonance imaging and two consecutive biopsies preoperatively.


Keywords

Endocervical polyp; Mullerian adenosarcoma; Uterine cervix.


Cite and Share

Eun Hee Yu,Yong Jung Song,Seul Yi Lee,Seo Yoon Hwang,Nam Kyung Lee,Kyung Un Choi,Dong Soo Suh,Ki Hyung Kim. Mullerian adenosarcoma of the uterine cervix misdiagnosed as an endocervical polyp on magnetic resonance imaging and two preoperative consecutive biopsies: A diagnostic challenge. European Journal of Gynaecological Oncology. 2020. 41(6);1045-1049.

References

[1] Clement P.B., Scully R.E.: “Mullerian adenosarcoma of the uterus: A clinicopathologic analysis of 100 cases with a review of the literature”. Hum. Pathol., 1990, 21, 363-381.

[2] Manoharan M., Azmi M., Soosay G., Mould T., Weekes A.: “Mullerian adenosarcoma of uterine cervix: Report of three cases and review of literature”. Gynecol. Oncol., 2007, 105, 256-260.

[3] Seagle B.L., Kanis M., Strohl A.E., Shahabi S.: “Survival of women with Mullerian adenosarcoma: a national cancer data base study”. Gynecol. Oncol., 2016, 143, 636-641.

[4] Yuan Z., Shen K., Yang J., Cao D., Zhang Y., Zhou H., et al.: “Uter-ine adenosarcoma: a retrospective 12-year single-center study”. Front. Oncol., 2020, 9237.

[5] Grasel R.P., Outwater E.K., Siegelman E.S., Capuzzi D., Parker L., Hussain S.M.: “Endometrial polyps: MR imaging features and distinction from endometrial carcinoma”. Radiology, 2000, 214, 47-52.

[6] Bakir B., Sanli S., Bakir V.L., Ayas S., Yildiz S.O., Iyibozkurt A.C., et al.: “Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening”. Clin. Imaging, 2017, 41, 86-94.

[7] Takeuchi M., Matsuzaki K., Nishitani H.: “Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion”. Acta Radiol., 2009, 50, 947-953.

[8] Hase S., Mitsumori A., Inai R., Takemoto M., Matsubara S., Aka-matsu N., et al.: “Endometrial polyps: MR imaging features”. Acta Med. Okayama, 2013, 66, 475.

[9] Whittaker C.S., Coady A., Culver L., Rustin G., Padwick M., Pad-hani A.R.: “Diffusion-weighted MR imaging of female pelvic tumors: a pictorial review”. Radiographics, 2009, 29, 759-774.

[10] McVeigh P.Z., Syed A.M., Milosevic M., Fyles A., Haider M.A.: “Diffusion-weighted MRI in cervical cancer”. Eur. Radiol., 2008, 18, 1058-1064.

[11] Kuang F., Yan Z., Li H., Feng H.: “Diagnostic accuracy of diffusion-weighted MRI for differentiation of cervical cancer and benign cervical lesions at 3.0T: Comparison with routine MRI and dynamic contrast-enhanced MRI”. J. Magn. Reson. Imaging, 2015, 42, 1094-1099.

[12] Chin P., Chia Y., Lim Y., Yam K.: “Diagnosis and management of Mullerian adenosarcoma of the uterine cervix”. Int. J. Gynaecol. Obstet., 2013, 121, 229-232.

[13] Soslow R.A., Ali A., Oliva E.: “Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases”. Am. J. Surg., 2008, 32, 1013-1021.

[14] Gallardo A., Prat J.: “Mullerian adenosarcoma”. Am. J. Surg., 2009, 33, 278-288.

[15] McCluggage W.G.: “Mullerian adenosarcoma of the female genital tract”. Adv. Anat. Pathol., 2010, 17, 122-129.

[16] Kudela E., Nachajova M., Balharek T., Gabonova E., Danko J.: “Mullerian adenosarcomas of the uterine cervix with sarcomatous overgrowth”. Curr. Probl. Cancer, 2019, 43, 371-376.

[17] Togami S., Kawamura T., Fukuda M., Yanazume S., Kamio M., Kobayashi H.: “Clinical management of uterine cervical mullerian adenosarcoma: a clinicopathological study of six cases and review of the literature”. Taiwan J. Obstet. Gynecol., 2018, 57, 479-482.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top