Endometrioid adenocarcinoma with choriocarcinoma differentiation: A case report

Rationale: Endometrioid adenocarcinoma is a common type of endometrial cancer, while endometrioid adenocarcinoma with choriocarcinoma is rare. Method: This report introduced a rare case of endometrial adenocarcinoma with choriocarcinoma with its slight atypical clinical symptom, diagnostic steps, surgical and medical management. Additionally, a discussion addressed the prior reports of endometrioid adenocarcinoma with choriocarcinoma differentiation encountered over the decades. Implication: We wrote this article so that clinicians in the field could have a better understanding of endometrioid adenocarcinoma with choriocarcinoma, and the improvement of the levels of diagnosis and treatment for such patients.

Endometrioid adenocarcinoma; Choriocarcinoma; Uterine cavity; Pelvic MRI; Hysteroscopy; Cervical biopsy.

[1] Srikantia N., Rekha B., Rajeev A., Kalyan S.: “Endometrioid en-dometrial adenocarcinoma in a premenopausal woman with multiple organ metastases”. Indian J. Med. Paediatr. Oncol., 2009, 30, 80- 83.

[2] Han J., Ki E.Y., Rha S.E., Hur S., Lee A.: “Dedifferentiated en-dometrioid carcinoma of the uterus: report of four cases and review of literature”. World J. Surg. Oncol., 2017, 15, 17.

[3] International Classification of Diseases for Oncology. (n.d.). Retrieved September 7, 2018, from http://codes.iarc.fr/code/521.

[4] Ishida M., Okabe H.: “Endometrioid adenocarcinoma with chorio-carcinomatous differentiation: A case report and review of the literature”. Oncol. Lett., 2013, 6, 655-658.

[5] Yamamoto E.: “Ovary: Choriocarcinoma”. Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008, 13, 683-685.

[6] Civantos F., Rywlin A.M.: “Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins”. Cancer, 1972, 29, 789-798.

[7] Savage J., Subby W., Okagaki T.: “Adenocarcinoma of the en-dometrium with trophoblastic differentiation and metastases as choriocarcinoma: A case report”. Gynecol. Oncol., 1987, 26, 257-262.

[8] Pesce C., Merino M.J., Chambers J.T., Nogales F.: “Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer”. Cancer, 1991, 68, 1799-1802.

[9] Kalir T., Seijo L., Deligdisch L., Cohen C.: “Endometrial Adenocar-cinoma with choriocarcinomatous differentiation in an elderly virginal woman”. Int. J. Gynecol. Pathol., 1995, 14, 266-269.

[10] Bradley C.S., Benjamin I., Wheeler J.E., Rubin S.C.: “Endometrial adenocarcinoma with trophoblastic differentiation”. Gynecol. Oncol., 1998, 69, 74-77.

[11] Tunc M., Simsek T., Trak B., Uner M.: “Endometrium adenocarci-noma with choriocarcinomatous differentiation: a case report”. Eur. J. Gynaecol. Onco., 19, 489-491.

[12] Yamada T., Mori H., Kanemura M., Ohmichi M., Shibayama Y.: “Endometrial carcinoma with choriocarcinomatous differentiation: A case report and review of the literature”. Gynecol. Oncol., 2009, 113, 291-294.

[13] Akbulut M., Tosun H., Soysal M.E., Oztekin O.: “Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature”. Arch. Gynecol. Obstet., 2008, 278, 79-84.

[14] Horn L.C., Hänel C., Bartholdt E., Dietel J..: “Serous carcinoma of the endometrium with choriocarcinomatous differentiation”. Int. J. Gynecol. Pathol., 2006, 25, 247-251.

[15] Black K., Sykes P., Östör A.G.: “Trophoblastic differentiation in an endometrial carcinoma”. Aust. N. Z. J. Obstet. Gynaecol., 1998, 38, 472- 473.

[16] Nguyen C.P., Levi A.W., Montz F.J., Bristow R.E.: “Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus”. Gynecol. Oncol., 2000, 79, 499-503.

[17] Shintaku M., Kariya M., Shime H., Ishikura H.: “Adenocarcinoma of the Uterine Cervix with Choriocarcinomatous and Hepatoid Differentiation: Report of a Case”. Int. J. Gynecol. Pathol., 2000, 19, 174- 178.