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Port site implantation of clear cell carcinoma after laparoscopic ovarian cystectomy

  • Joseph J. Noh1
  • Kyue-Hee Choi2
  • Hyun-Soo Kim2
  • Jeong-Won Lee1,*,

1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351 Seoul, South Korea

2Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351 Seoul, South Korea

DOI: 10.31083/j.ejgo.2021.01.2209 Vol.42,Issue 1,February 2021 pp.174-178

Submitted: 03 August 2020 Accepted: 20 October 2020

Published: 15 February 2021

*Corresponding Author(s): Jeong-Won Lee E-mail:


Despite the fact that laparoscopic surgery has clearly shown benefits in patients with benign ovarian tumor, concerns remain regarding port site metastasis especially when final pathology reveals malignancy. Port site metastasis has been reported in early stages of malignant diseases. However, to our knowledge, there are no reports of port site implantation of malignant cells after laparoscopic surgery for benign disease. We present a 39-year-old woman who had undergone laparoscopic ovarian cystectomy for benign disease, and developed clear cell carcinoma at the site of trocar insertion 11 months after the initial operation. It is possible that the cancer was missed at the time of the initial surgery. Numerous factors have been suggested in the development of port site metastasis including aerosolization of tumor cells, lack of local immune response by the host and unskilled surgical techniques. A careful preoperative evaluation and meticulous laparoscopic maneuvers are the best way to prevent such occurrence.


Laparoscopy; Port site metastasis; Clear cell carcinoma; Ovarian cancer

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Joseph J. Noh,Kyue-Hee Choi,Hyun-Soo Kim,Jeong-Won Lee. Port site implantation of clear cell carcinoma after laparoscopic ovarian cystectomy. European Journal of Gynaecological Oncology. 2021. 42(1);174-178.


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