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New treatment strategy for ovarian cancer with a BRCA gene mutation

  • Tadahiro Shoji1,*,
  • Kotoka Kikuchi1
  • Hayato Kogita1
  • Nanako Jonai1
  • Hidetoshi Tomabechi1
  • Akiko Kudoh1
  • Eriko Takatori1
  • Takayuki Nagasawa1
  • Masahiro Kagabu1
  • Tsukasa Baba1

1Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 028-3695 Yahaba, Japan

DOI: 10.31083/j.ejgo.2021.01.2251 Vol.42,Issue 1,February 2021 pp.1-9

Submitted: 22 September 2020 Accepted: 04 December 2020

Published: 15 February 2021

(This article belongs to the Special Issue BRCA and Ovarian Cancer)

*Corresponding Author(s): Tadahiro Shoji E-mail: tshoji@iwate-med.ac.jp

Abstract

Mutated BRCA1/2 genes have been identified as causative genes for ovarian cancer, and it has been reported that 10%–20% of all epithelial ovarian cancers have a BRCA mutation. As novel treatment drugs utilizing this BRCA gene mutation, significant attention has been paid to adenine dinucleotide poly (ADP-ribose) polymerase inhibitors. Among them, olaparib has been reported to be useful in patients with a BRCA mutation in Study 19 and SOLO-2 trials. It is important to establish a system for genetic counseling and to perform BRCA gene testing in patients with ovarian cancer. For patients with BRCA -mutated advanced cancer, if adequate response to chemotherapy has been achieved, olaparib is recommended as maintenance therapy for both advanced and recurrent cases. For patients without BRCA gene mutation, bevacizumab combined with chemotherapy or as maintenance therapy is also an option.


Keywords

Ovarian cancer; BRCA mutation; PARP inhibitor


Cite and Share

Tadahiro Shoji,Kotoka Kikuchi,Hayato Kogita,Nanako Jonai,Hidetoshi Tomabechi,Akiko Kudoh,Eriko Takatori,Takayuki Nagasawa,Masahiro Kagabu,Tsukasa Baba. New treatment strategy for ovarian cancer with a BRCA gene mutation. European Journal of Gynaecological Oncology. 2021. 42(1);1-9.

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