Effect of triptorelin on the protection from damage on mouse ovarian cells caused by tripterygium polyglycoside

Objective: To investigate the effect of triptorelin on the protection of tripterygium polyglycoside-induced damage to ovarian function on mouse ovarian cells through the study of Bcl-2 and Smac. Method: Thirty female SD mice with normal estrous cycle were selected and randomLy divided into three groups of 10 mice each. Group A (blank control group); Group B (tripterygium glycoside group); Group C (tripterygium glycoside + triptorelin group). For all three groups, the drug was stopped for 3 weeks and all mice were then sacrificed. Ovaries were taken to detect the expression of Bcl-2 and Smac in ovarian tissue. Results: Compared with the blank control group, the expression of Bcl-2 in the tripterygium polyglycoside group was reduced and the expression of Smac was enhanced, while for the triptorelin group, increased expression of Bcl-2 and decreased expression of Smac were observed with a statistical significance (P < 0.05). Conclusions: Tripterygium polyglycoside can cause damage to ovarian function in female mice; Triptorelin has a protective effect on tripterygium polyglycoside-induced damage to ovarian function in female mice.

Triptorelin; Tripterygium; Ovarian function; Bcl-2; Smac

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