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Characterization of risk factors and timing of venous thromboembolism in patients with uterine carcinosarcoma
1Department of Obstetrics & Gynecology and Women’s Health, Division of Gynecologic Oncology, Montefiore Medical Center, Bronx, NY 10467, USA
2Department of Epidemiology and Population Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
3Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
DOI: 10.31083/j.ejgo.2021.03.2330 Vol.42,Issue 3,June 2021 pp.488-493
Submitted: 28 November 2020 Accepted: 31 December 2020
Published: 15 June 2021
*Corresponding Author(s): Rachel Borczuk E-mail: borczuk@mail.einstein.yu.edu
*Corresponding Author(s): Nicole S. Nevadunsky E-mail: nnevadun@montefiore.org
Objectives: The purpose of this study was to evaluate the timing and risk factors associated with venous thromboembolism in women with uterine carcinosarcoma in a racially and ethnically diverse urban population. Methods: A retrospective cohort study was performed with all women diagnosed with carcinosarcoma from 2005–2018 at Montefiore Medical Center in Bronx, NY. Data regarding patient demographics, medical comorbidities, treatment course, Khorana score and timing of thromboembolic events were abstracted. A Cox proportional hazards model which included time-dependent covariates for treatment course variables was estimated to examine the association between patient-related variables and the incidence and timing of venous thromboembolism. Results: Forty (31%) of 130 included patients developed venous thromboembolism and there were no significant associations between patient demographics, medical comorbidities, or cancer treatment with thromboembolic events. Being within 6 weeks of surgery was associated with a higher hazard of venous thromboembolism (HR 3.8, 95% CI [1.09–13.50], P = 0.04). Thirty-two (80%) patients who developed venous thromboembolism did so outside of the perioperative window. Patients receiving chemotherapy with a Khorana score
Uterine carcinosarcoma; Venous thromboembolism; Khorana score; Thromboprophylaxis
Rachel Borczuk,Gregory M. Gressel,Nicole Vilardo,Ken Y. Lin,Dennis Y. Kuo,Melissa Fazzari,Nicole S. Nevadunsky. Characterization of risk factors and timing of venous thromboembolism in patients with uterine carcinosarcoma. European Journal of Gynaecological Oncology. 2021. 42(3);488-493.
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