Diagnostic value of different colposcopy evaluation methods for high-grade squamous intraepithelial lesions and cervical cancer
1Department of Gynecology, The Second Affiliated Hospital of Jiaxing University, 314000 Jiaxing, Zhejiang Province, China
DOI: 10.31083/j.ejgo.2021.03.2347 Vol.42,Issue 3,June 2021 pp.463-469
Submitted: 12 December 2020 Accepted: 28 February 2021
Published: 15 June 2021
Objective: This study aimed to compare the diagnostic value of R-way, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC), and Reid colposcopy evaluation system for high-grade squamous intraepithelial lesions and cervical cancer (HSIL+). Methods: A total of 987 cases were referred for vaginal microscopic examination, using R-way system, IFCPC and Reid examination, and diagnostic capabilities of the methods for detecting HSIL+ were compared. Results: Using cervical biopsy or conization as the gold standard, in total 170 women (17.2%) had histologically confirmed HSIL+ including 36 women (3.6%) with invasive cervical cancer. The sensitivity for HSIL+ using the three different colposcopy evaluation methods were 74.7% (127/170), 78.2% (133/170) and 62.9% (107/170) for IFCPC, R-way and Reid. Consistency with histopathology was 69.00%, 75.28% and 55.32%, Kappa values were 0.517, 0.599 and 0.310, respectively. Based on HSIL, sensitivity, specificity, PPV and NPV of IFCPC and R-way pair for HSIL+ were better than those of Reid. McNemar test results revealed significant differences between R-way and IFCPC and between Reid and IFCPC for HSIL+ (
Colposcopy; Cervical screening; High-grade squamous intraepithelial lesions (HSIL); IFCPC; Reid
Fang Liu,Yufang Zhang,Xinyi Xia,Jin Han,Danhong Hu. Diagnostic value of different colposcopy evaluation methods for high-grade squamous intraepithelial lesions and cervical cancer. European Journal of Gynaecological Oncology. 2021. 42(3);463-469.
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