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Primary ovarian non-Hodgkin’s lymphoma: a case series and a review of literature

  • Hui-Ting Xiao1
  • Li Zhang1
  • Ke Wang1,*,

1Department of Gynecologic Oncology, Tianjin Medical University Cancer institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tian Jin, TianJin’s Clinical Research Center for Cancer, 300060 Tianjin, China

DOI: 10.31083/j.ejgo.2021.03.2377 Vol.42,Issue 3,June 2021 pp.561-566

Submitted: 12 January 2021 Accepted: 26 February 2021

Published: 15 June 2021

*Corresponding Author(s): Ke Wang E-mail: wangke@tjmuch.com

Abstract

Objectives: We report nine cases of primary ovarian non-Hodgkin’s lymphoma (PONHL). Materials and methods: From January 2000 to February 2020, we retrospectively analyzed nine patients with PONHL admitted to our hospital. Their clinicopathologic features, treatments, and outcomes were summarized. Results: This study included eight cases of DLBCLs and one case of T-cell origin. Their presentations included abdominal pain, abdominal distension, and a pelvic mass, and one had a history of B symptoms. Imaging features revealed large, solid, and homogenous adnexal lesions. Four cases had bilateral ovary involvement and one had abdominal bloody ascites. Intraoperative frozen section analysis showed that five patients had lymphoma, and four had incorrect diagnoses. All patients received surgical treatment and adjuvant chemotherapy. Three patients died of their disease, and six are alive and cancer-free. Conclusions: Preoperative diagnosis of PONHL is difficult. Correct frozen section analysis is a key determinant for guiding conservative therapy. Adjuvant R-CHOP chemotherapy might be an effective regimen.

Keywords

Lymphoma and non-Hodgkin's disease; Ovarian tumors; Ovarian lymphoma; Primary ovarian lymphoma

Cite and Share

Hui-Ting Xiao,Li Zhang,Ke Wang. Primary ovarian non-Hodgkin’s lymphoma: a case series and a review of literature. European Journal of Gynaecological Oncology. 2021. 42(3);561-566.

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