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Multi-modality therapies for advanced small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): three case reports and literature review

  • Qin Han1,*,
  • Hongyan Guo1

1Department of Obstetrics and Gynecology, The Third Hospital of Peking University, 100191 Beijing, China

DOI: 10.31083/j.ejgo4301002 Vol.43,Issue 1,February 2022 pp.153-159

Submitted: 22 September 2021 Accepted: 01 November 2021

Published: 15 February 2022

*Corresponding Author(s): Qin Han E-mail:


Background: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. Most SCCOHT patients present with advanced disease and have a very poor prognosis. Although several therapeutic regimens have been proposed, there is no consensus on the optimal treatment strategy. Case: Herein, we describe three cases of advanced-stage SCCOHT aged from16 to 36 treated with cytoreductive surgery and chemotherapy with or without immune checkpoint blockade treatment. With different strategy, the patients showed utterly different outcomes. Conclusion: The cases highlight the importance of prompt diagnosis as well as early, aggressive, and combined modality treatment of SCCOHT. We believe that improved therapies could result in more young patients surviving SCCOHT.


Small cell carcinoma of the ovary hypercalcemic type (SCCOHT); Advanced stage; Tumor immunotargeted therapy

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Qin Han,Hongyan Guo. Multi-modality therapies for advanced small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): three case reports and literature review. European Journal of Gynaecological Oncology. 2022. 43(1);153-159.


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