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Original Research

Open Access

Total parietal peritonectomy for 61 patients: a retrospective study

  • Ralph Saadeh1,*,
  • Angélique Berthet1
  • Séverine Marchant1
  • François Kraus1
  • Othman Aissaoui1
  • Fabrice Narducci1,2
  • Eric Leblanc1,2
  • Délphine Hudry1,2

1Department of gynecologic oncology, Centre Oscar Lambret, 59000 Lille, France

2Université Lille, Inserm, U-1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse-PRISM, 59650 Villeneuve d’Ascq, France

DOI: 10.31083/j.ejgo4301009 Vol.43,Issue 1,February 2022 pp.17-25

Submitted: 03 November 2021 Accepted: 15 December 2021

Published: 15 February 2022

*Corresponding Author(s): Ralph Saadeh E-mail: ralphsaadeh@gmail.com

Abstract

Objective: To evaluate the morbidity of total parietal peritonectomy (TPP) during cytoreduction surgery, and its impact on the site of recurrence of different peritoneal surface malignancies (PSM). Methods: We led a retrospective study in a French tertiary cancer institution (Centre Oscar Lambret - Lille) experienced in treating PSM over a 6-year period from 2012 to 2018. All patients underwent a total parietal peritonectomy during a debulking surgery for PSM including ovarian cancer, appendiceal pseudomyxoma peritonei or peritoneal mesothelioma. Results: Among the 61 patients included in this study, 49 patients(80.3%) had an ovarian cancer. The rate of complete tumor resection reached 86.9% with almost 69% of surgeries being highly complex. 73.8% were transfused during the surgical procedure. The median length of hospital stay was 10 days including 7 days in Intensive Care Unit. Overall, 19 patients (31.1%) had an early postoperative complication, including 3 with a grade IIIB complication of Clavien Dindo classification. With a median follow-up of 30 months, the estimated disease-free survival in the ovarian cancer subgroup who had an initial peritonectomy (n = 42) was 84.7% at 1 year and 12.0% at 3 year. The main site of first and second recurrence was peritoneal (42% and 14%). Conclusion: TPP is a safe surgical procedure to treat peritoneal surface malignancies and their recurrences with a low rate of grade IIIB morbidity and no treatment-related death and allow optimal surgery. In this study there is no atypical recurrence site, such as abdominal muscle involvement.


Keywords

Ovarian cancer; Peritonectomy; Primary surgery debulking; Interval debulking surgery; Neo-adjuvant chemotherapy

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Ralph Saadeh,Angélique Berthet,Séverine Marchant,François Kraus,Othman Aissaoui,Fabrice Narducci,Eric Leblanc,Délphine Hudry. Total parietal peritonectomy for 61 patients: a retrospective study. European Journal of Gynaecological Oncology. 2022. 43(1);17-25.

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