Prognostic value of matrix metalloproteinase 2 protein expression in ovarian cancer is age- and stage-dependent
1Center of Excellence in Genomic Medicine Research, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
2Medical Laboratory Department, Faculty of Applied Medical Sciences, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
3Biological Sciences Department, Faculty of Science, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
4Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, 14812 Riyadh, Saudi Arabia
5Department of Pathology, Faculty of Medicine, King Abdulaziz University Hospital, 21589 Jeddah, Saudi Arabia
6Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University Hospital, 21589 Jeddah, Saudi Arabia
7Laboratoire de Parasitologie-Mycologie, Pasteur Institute of Tunis, 1002 Tunis, Tunisia
8Faculty of Medicine, King Abdulaziz University Hospital, 21589 Jeddah, Saudi Arabia
9Surgical Research Section, Department of Surgery, Hamad Medical Corporation, 55867 Doha, Qatar
DOI: 10.31083/j.ejgo4301010 Vol.43,Issue 1,February 2022 pp.26-35
Submitted: 12 September 2021 Accepted: 17 November 2021
Published: 15 February 2022
Objective: Matrix metalloproteinase 2 (MMP2) has been associated with tumor development and invasion; however, the information available regarding its prognostic value in ovarian cancer (OC), especially in the Arabian Peninsula, is limited. The aim of this retrospective study was to analyze MMP2 protein expression and assess its prognostic value. Methods: In total, 245 formalin-fixed and paraffin-embedded (FFPE) primary OC tissue samples were randomly collected from patients with available clinicopathological data, including disease of all stages and all histological subtypes. MMP2 protein expression was measured using automated tissue microarray and immunohistochemistry techniques. Statistical analyses were performed using SPSS, with p
Ovarian cancer; Matrix metalloproteinase; MMP2; Prognosis; Tissue microarray; Age; Stage
Mourad Assidi,Mohammad Alam Jafri,Muhammad Abu-Elmagd,Salina Saddi,Safia Messaoudi,Mahmood Rasool,Jaudah AlMaghrabi,Nisreen Anfinan,Hanen Chelbi,Maram Sait,Abdelfatteh El Omri,Hesham Sait,Hussain Basalamah,Khalid Sait,Abdelbaset Buhmeida. Prognostic value of matrix metalloproteinase 2 protein expression in ovarian cancer is age- and stage-dependent. European Journal of Gynaecological Oncology. 2022. 43(1);26-35.
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