Title
Author
DOI
Article Type
Special Issue
Volume
Issue
PARP inhibition in ovarian cancer: what is still missing?
1Ludwig Institute for Cancer Research, Bâtiment AGORA, 1005 Lausanne, Switzerland
2Department of Gynecology, CHUV-Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
3Department of Oncology, Immuno-Oncology Service, CHUV-Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
DOI: 10.31083/j.ejgo4301016 Vol.43,Issue 1,February 2022 pp.143-145
Submitted: 11 October 2021 Accepted: 19 November 2021
Published: 15 February 2022
*Corresponding Author(s): Matteo Morotti E-mail: drmorottimatteo@gmail.com
Matteo Morotti,Eleonora Ghisoni. PARP inhibition in ovarian cancer: what is still missing?. European Journal of Gynaecological Oncology. 2022. 43(1);143-145.
[1] Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY. Ovarian cancer. Nature Reviews Disease Primers. 2016; 2: 16061.
[2] Farmer H, McCabe N, Lord CJ, Tutt ANJ, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005; 434: 917–921.
[3] Bell D, Berchuck A, Birrer M, Chien J, Cramer DW, Dao F, et al. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474: 609–615.
[4] Ray-Coquard I, Pautier P, Pignata S, Pérol D, González-Martín A, Berger R, et al. Olaparib plus Bevacizumab as first-Line Maintenance in Ovarian Cancer. New England Journal of Medicine. 2019; 381: 2416–2428.
[5] Coleman RL, Fleming GF, Brady MF, Swisher EM, Steffensen KD, Friedlander M, et al. Veliparib with first-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer. New England Journal of Medicine. 2019; 381: 2403–2415.
[6] González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, et al. Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. New England Journal of Medicine. 2019; 381: 2391–2402.
[7] Frey MK, Pothuri B. Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature. Gynecologic Oncology Research and Practice. 2017; 4: 4.
[8] Nguyen L, W. M. Martens J, Van Hoeck A, Cuppen E. Pancancer landscape of homologous recombination deficiency. Nature Communications. 2020; 11: 5584.
[9] Pellegrino B, Mateo J, Serra V, Balmaña J. Controversies in oncology: are genomic tests quantifying homologous recombination repair deficiency (HRD) useful for treatment decision making? ESMO Open. 2019; 4: e000480.
[10] Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, et al. A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients. Clinical Cancer Research. 2018; 24: 4482–4493.
[11] Gulhan DC, Lee JJ, Melloni GEM, Cortés-Ciriano I, Park PJ. Detecting the mutational signature of homologous recombination deficiency in clinical samples. Nature Genetics. 2019; 51: 912–919.
[12] Dias MP, Moser SC, Ganesan S, Jonkers J. Understanding and overcoming resistance to PARP inhibitors in cancer therapy. Nature Reviews Clinical Oncology. 2021; 18: 773–791.
[13] Färkkilä A, Rodríguez A, Oikkonen J, Gulhan DC, Nguyen H, Domínguez J, et al. Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells. Cancer Research. 2021; 81: 2774–2787.
[14] Curtin NJ, Szabo C. Poly(ADP-ribose) polymerase inhibition: past, present and future. Nature Reviews Drug Discovery. 2020; 19: 711–736.
[15] Strickland KC, Howitt BE, Shukla SA, Rodig S, Ritterhouse LL, Liu JF, et al. Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget. 2016; 7: 13587–13598.
[16] Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Reports. 2021; 36: 109412.
[17] Motwani M, Pesiridis S, Fitzgerald KA. DNA sensing by the cGAS–STING pathway in health and disease. Nature Reviews Genetics. 2019; 20: 657–674.
[18]
Ding L, Kim H, Wang Q, Kearns M, Jiang T, Ohlson CE, et al. PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Reports. 2018; 25: 2972–2980.e5.
[19]
Shen J, Zhao W, Ju Z, Wang L, Peng Y, Labrie M, et al. PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. Cancer Research. 2019; 79: 311–319.
[20] Jiao S, Xia W, Yamaguchi H, Wei Y, Chen M, Hsu J, et al. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression. Clinical Cancer Research. 2017; 23: 3711–3720.
[21] Li A, Yi M, Qin S, Chu Q, Luo S, Wu K. Prospects for combining immune checkpoint blockade with PARP inhibition. Journal of Hematology & Oncology. 2019; 12: 98.
Web of Science (WOS) (On Hold)
Journal Citation Reports/Science Edition
Google Scholar
JournalSeek
Top