Is screening for endometrial cancer necessary in asymptomatic women treated with tamoxifen for breast cancer?
1Department of Obstetrics and Gynecology, Chonnam National University Medical School, 61469 Gwangju, Republic of Korea
DOI: 10.31083/j.ejgo4302022 Vol.43,Issue 2,April 2022 pp.169-174
Submitted: 09 December 2021 Accepted: 20 January 2022
Published: 15 April 2022
† These authors contributed equally.
Objective: This study aimed to investigate the endometrial pathology findings and to determine the appropriate diagnostic approach to assess for potential endometrial malignancy or premalignant pathology in women treated with tamoxifen for breast cancer. Methods: We retrospectively reviewed the medical records of 162 patients taking tamoxifen and who underwent endometrial biopsy. We compared the clinical features of the patients with endometrial intraepithelial neoplasia or cancer (EIN/EC group) and the patients with other pathologic results (others group). Results: EIN or EC was found in ten patients (6.2%). While 70.0% of EIN/EC group received tamoxifen treatment for more than 3 years, 71.7% of the others group received less than 3 years (p
breast cancer; tamoxifen; endometrial pathology; vaginal bleeding; endometrial thickness
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