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Original Research

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Evaluation of tumor size in cervix cancer patients treated with surgery: ultrasonography or MRI?

  • Özer Birge1,*,
  • Mehmet Sait Bakır1
  • Saliha Sagnic1
  • Selen Doğan1
  • Hasan Aykut Tuncer1
  • Tayup Simsek1

1Department of Gynecology and Obstetrics, Akdeniz University, 07100 Antalya, Turkey

DOI: 10.31083/j.ejgo4302035 Vol.43,Issue 2,April 2022 pp.278-284

Submitted: 13 November 2021 Accepted: 20 December 2021

Published: 15 April 2022

*Corresponding Author(s): Özer Birge E-mail: ozbirge@gmail.com

Abstract

Objective: This study aims to compare tumor diameters measured by transvaginal ultrasonography and MRI in cervical cancer. Materials and methods: The study includes 127 cervical cancer patients diagnosed and treated at Akdeniz University Faculty of Medicine between January 2002 and December 2019. Data were collected retrospectively using the electronic archive system of the hospital. Patients with pathologically unknown tumor diameters were excluded from the study. Data were tested for normal distribution, and the mean, standard deviation, median, min-max values, and frequencies were used as descriptive statistics. Categorical data were expressed as numbers and percentages (%). The Student’s t-test, one of the parametric tests, was used to compare tumor diameters. Statistical Package for the Social Sciences (SPSS) 23 software (IBM Corp., Chicago, IL, USA) was used for data analysis. A p-value less than 0.05 was considered statistically significant in all tests. Results: The mean age of patients included in the study was 49.55 ± 11.67 years. Of all patients, 79.5% had a normal delivery. 87 (68%) of the patients were not using any contraceptive method, with 0.7%, condom protection was the least. Among the complaints of patients at admission, postcoital vaginal bleeding was the most common complaint with 42.5%, and asymptomatic patients were the second most common with 22%. Human papillomavirus (HPV) status was unknown in the vast majority of patients (91.3%). Regarding the stage status, stage 1b2 was the most frequently seen stage with 29 patients. Tumor histology revealed SCC in 80.3% and adenocarcinoma in 18.1%. The mean tumor diameter measured by transvaginal ultrasonography (TVS) was 3.30 ± 1.95, by magnetic resonance imaging (MRI) was 3.37 ± 2.03, and the pathologically measured tumor diameter was 3.17 ± 1.86. There was no statistically significant difference between the mean tumor diameter measured by TVS and MRI, MRI and pathology, and TVS and pathology (p: 0.769, p: 0.589, p: 0.891, respectively). Conclusion: When used by specialists experienced in the field of gynecological oncology, ultrasonography can be considered as effective as MRI, especially in tumor size measurement in cervical cancer, due to its ease of use, cheapness, and easy accessibility in regions with low socioeconomic status.


Keywords

cervical cancer; transvaginal ultrasonography; MRI; postcoital bleeding; tumor diameter

Cite and Share

Özer Birge,Mehmet Sait Bakır,Saliha Sagnic,Selen Doğan,Hasan Aykut Tuncer,Tayup Simsek. Evaluation of tumor size in cervix cancer patients treated with surgery: ultrasonography or MRI?. European Journal of Gynaecological Oncology. 2022. 43(2);278-284.

References

[1] Salvo G, Odetto D, Pareja R, Frumovitz M, Ramirez PT. Revised 2018 International Federation of Gynecology and Obstetrics (FIGO) cervical cancer staging: a review of gaps and questions that remain. International Journal of Gynecologic Cancer. 2020; 30: 873–878.

[2] Berek JS, Matsuo K, Grubbs BH, Gaffney DK, Lee SI, Kilcoyne A, et al. Multidisciplinary perspectives on newly revised 2018 FIGO staging of cancer of the cervix uteri. Journal of Gynecologic Oncology. 2019; 30: e40.

[3] Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri. International Journal of Gynaecology and Obstetrics. 2018; 143: 22–36.

[4] National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology cervical cancer (version I. 2018). 2018. Available at: https://www.nccn.org/professionals/physici an_gls/default.Aspx (Accessed: 26 June 2018).

[5] Canaz E, Ozyurek ES, Erdem B, Aldikactioglu Talmac M, Yildiz Ozaydin I, Akbayir O, et al. Preoperatively Assessable Clinical and Pathological Risk Factors for Parametrial Involvement in Surgically Treated FIGO Stage IB-IIA Cervical Cancer. International Journal of Gynecological Cancer. 2017; 27: 1722–1728.

[6] Hricak H, Powell CB, Yu KK, Washington E, Subak LL, Stern JL, et al. Invasive cervical carcinoma: role of MR imaging in pretreatment work-up–cost minimization and diagnostic efficacy analysis. Radiology. 1996; 198: 403–409.

[7] Hricak H. First open trial of the American College of Radiology Imaging Network: proper imaging approach for invasive cervical cancer. Radiology. 2002; 225: 634–635.

[8] Okamoto Y, Tanaka YO, Nishida M, Tsunoda H, Yoshikawa H, Itai Y. MR Imaging of the Uterine Cervix: Imaging-Pathologic Correlation. RadioGraphics. 2003; 23: 425–445.

[9] Rockall AG, Ghosh S, Alexander-Sefre F, Babar S, Younis MTS, Naz S, et al. Can MRI rule out bladder and rectal invasion in cervical cancer to help select patients for limited EUA? Gynecologic Oncology. 2006; 101: 244–249.

[10] Sozzi G, Berretta R, Fiengo S, Ferreri M, Giallombardo V, Finazzo F, et al. Integrated presurgical diagnostic algorithm to define extent of disease in cervical cancer. International Journal of Gynecologic Cancer. 2020; 30: 16–20.

[11] Testa AC, Ludovisi M, Manfredi R, Zannoni G, Gui B, Basso D, et al. Transvaginal ultrasonography and magnetic resonance imaging for assessment of presence, size and extent of invasive cervical cancer. Ultrasound in Obstetrics and Gynecology. 2009; 34: 335–344.

[12] Fischerova D, Cibula D, Stenhova H, Vondrichova H, Calda P, Zikan M, et al. Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. International Journal of Gynecological Cancer. 2008; 18: 766–772.

[13] Gaurilcikas A, Vaitkiene D, Cizauskas A, Inciura A, Svedas E, Maciuleviciene R, et al. Early-stage cervical cancer: agreement between ultrasound and histopathological findings with regard to tumor size and extent of local disease. Ultrasound in Obstetrics & Gynecology. 2011; 38: 707–715.

[14] Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, et al. Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines. Obstetrics & Gynecology. 2019; 134: 49–57.

[15] Kato T, Takashima A, Kasamatsu T, Nakamura K, Mizusawa J, Nakanishi T, et al. Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-a). Gynecologic Oncology. 2015; 137: 34–39.

[16] Balleyguier C, Sala E, Da Cunha T, Bergman A, Brkljacic B, Danza F, et al. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. European Radiology. 2011; 21: 1102–1110.

[17] Hricak H, Lacey CG, Sandles LG, Chang YC, Winkler ML, Stern JL. Invasive cervical carcinoma: comparison of MR imaging and surgical findings. Radiology. 1988; 166: 623–631.

[18] Bipat S, Glas AS, van der Velden J, Zwinderman AH, Bossuyt PMM, Stoker J. Computed tomography and magnetic resonance imaging in staging of uterine cervical carcinoma: a systematic review. Gynecologic Oncology. 2003; 91: 59–66.

[19] Choi SH, Kim SH, Choi HJ, Park BK, Lee HJ. Preoperative magnetic resonance imaging staging of uterine cervical carcinoma: results of prospective study. Journal of Computer Assisted Tomography. 2004; 28: 620–627.

[20] Seki H, Azumi R, Kimura M, Sakai K. Stromal invasion by carcinoma of the cervix: assessment with dynamic MR imaging. American Journal of Roentgenology. 1997; 168: 1579–1585.

[21] Subak LL, Hricak H, Powell CB, Azizi L, Stern JL. Cervical carcinoma: computed tomography and magnetic resonance imaging for preoperative staging. Obstetrics and Gynecology. 1995; 86: 43–50.

[22] Park J, Kim EN, Kim D, Suh D, Kim J, Kim Y, et al. Comparison of the validity of magnetic resonance imaging and positron emission tomography/computed tomography in the preoperative evaluation of patients with uterine corpus cancer. Gynecologic Oncology. 2008; 108: 486–492.

[23] Malayeri AA, El Khouli RH, Zaheer A, Jacobs MA, Corona-Villalobos CP, Kamel IR, et al. Principles and applications of diffusion-weighted imaging in cancer detection, staging, and treatment follow-up. Radiographics. 2011; 31: 1773–1791.

[24] Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C. The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology. 2013; 266: 717–740.

added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology. 2013; 266: 717–740.


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