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Open Access Special Issue

Treatment Progress in Triple Negative Breast Cancer

  • Stefan Krämer1
  • Christoph Rogmans2
  • Dilek Saylan1
  • Dominique Friedrich1
  • Clayton Kraft1
  • Gunther Rogmans1
  • Marina Wirtz1
  • Michael Friedrich1,*,

1Department of Obstetrics and Gynecology, Helios Hospital, 47805 Krefeld, Germany

2Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany

DOI: 10.31083/j.ejgo4302040 Vol.43,Issue 2,April 2022 pp.341-352

Submitted: 22 November 2021 Accepted: 18 February 2022

Published: 15 April 2022

(This article belongs to the Special Issue Breast Cancer)

*Corresponding Author(s): Michael Friedrich E-mail: michael.friedrich@helios-gesundheit.de

Abstract

Triple-negative breast cancer (TNBC) lacks expression of the three biomarkers (the estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) protein) and are typically higher grade. While the triple-negative clinical phenotype is heterogeneous, the basal-like molecular subtype comprises a large proportion, particularly for breast cancer susceptibility gene 1 (BRCA1)-associated breast cancer. New treatment options are checkpoint inhibitors like inhibition of PD-L1 pathway with pembrolizumab and atezolizumab, parp-inhibition with olaparib or talozoparib and treatment with the an antibody drug conjugate sacituzumab-govitecan.


Keywords

breast cancer; triple negative; chemotherapy; immunoncology; PD -L1; Parp; pembrolizumab; atezolizumab; olaparib; talozoparib; sacituzumab-govitecan

Cite and Share

Stefan Krämer,Christoph Rogmans,Dilek Saylan,Dominique Friedrich,Clayton Kraft,Gunther Rogmans,Marina Wirtz,Michael Friedrich. Treatment Progress in Triple Negative Breast Cancer. European Journal of Gynaecological Oncology. 2022. 43(2);341-352.

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