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Uterine lipoleiomyoma: a benign entity with malignant transformation potential?

  • Yunzhe Wan1,†
  • Xiang Zhang2,†
  • Yue Sun1
  • Linping Wang3
  • Guoyan Liu1,*,

1Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, 300052 Tianjin, China

2Department of Gynecology and Obstetrics, The First Affiliated Hospital of Henan University of Science and Technology, 471003 Luoyang, Henan, China

3Department of Gynecology and Obstetrics, Zhejiang Hospital, 310030 Hangzhou, Zhejiang, China

DOI: 10.31083/j.ejgo4302042 Vol.43,Issue 2,April 2022 pp.363-367

Submitted: 09 January 2021 Accepted: 23 February 2021

Published: 15 April 2022

*Corresponding Author(s): Guoyan Liu E-mail: liuguoyan211@126.com

† These authors contributed equally.

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Abstract

Background: Uterine lipoleiomyoma is a rare lipomatous variant of uterine leiomyoma composed of a variable mixture of mature smooth muscle cells and adipocytes, typically found in peri or postmenopausal women. Malignancies arising from the tumor have rarely been reported though it is considered benign. Cases: We present three cases of uterine lipoleiomyoma and review literature to explore its etiology, characteristics, diagnosis and malignant transformation potential. Conclusion: Imaging examinations especially magnetic resonance imaging (MRI) play an important role in preoperative diagnosis. For large size and rapid growth of lipoleiomyoma, malignant transformation potential should be considered and surgery is required. Follow-up is still necessary.


Keywords

Differential diagnosis; Magnetic resonance imaging; Malignancy; Ultrasound; Uterine lipoleiomyoma

Cite and Share

Yunzhe Wan,Xiang Zhang,Yue Sun,Linping Wang,Guoyan Liu. Uterine lipoleiomyoma: a benign entity with malignant transformation potential?. European Journal of Gynaecological Oncology. 2022. 43(2);363-367.

URL:

https://www.ejgo.net/articles/10.31083/j.ejgo4302042

References

[1] Oh SR, Cho YJ, Han M, Bae JW, Park J, Rha S. Uterine lipoleiomyoma in peri or postmenopausal women. Journal of Menopausal Medicine. 2015; 21: 165–170.

[2] Scurry J, Hack M. Leiomyosarcoma arising in a lipoleiomyoma. Gynecologic Oncology. 1990; 39: 381–383.

[3] McDonald AG, Dal Cin P, Ganguly A, Campbell S, Imai Y, Rosenberg AE, et al. Liposarcoma arising in uterine lipoleiomy-oma: a report of 3 cases and review of the literature. American Journal of Surgical Pathology. 2011; 35: 221–227.

[4] Tyagi N, Tyagi R, Griffin Y. Uterine lipolemyoma. BMJ Case Reports. 2014; 2014: bcr2014207763.

[5] Terada T. Large lipoleiomyoma of the uterine body. Annals of Diagnostic Pathology. 2012; 16: 302–305.

[6] Raga F, Cholvi S, Esquembre MJ, Boigues D, Lucas C, Bonilla-Musoles F. Three-dimensional ultrasound radiance mode imaging of a uterine lipoleiomyoma. Medical Ultrasonography. 2016; 18: 247–249.

[7] Nayal B, Somal P, Rao A, Kumar P. Uterine lipoleiomyoma: a case report of a rare entity. International Journal of Applied and Basic Medical Research. 2016; 6: 134–136.

[8] Chu C, Tang Y, Chan TA, Wan Y, Fung K. Diagnostic challenge of lipomatous uterine tumors in three patients. World Journal of Radiology. 2012; 4: 58–62.

[9] Nazir HM, Mehta S, Seena CR, Kulasekaran N. Uterine lipoleiomyoma: a report of two cases. Journal of Clinical Imaging Science. 2017; 7: 26.

[10] Johari B, Koshy M, Sidek S, Hanafiah M. Lipoleiomyoma: a rare benign tumour of the uterus. BMJ Case Reports. 2014; 2014: bcr2014205814.

[11] Carvalho JF, Cubal A, Torres S, Morgado A, Oliveira C, do Carmo O. Preoperative diagnosis of a uterine lipoleiomyoma using transvaginal ultrasound: a case report of an unusual entity. Journal of Obstetrics and Gynaecology. 2014; 34: 281–282.

[12] Fujiwaki R, Ohnuma H, Miura H, Sawada K. Uterine lipoleiomyoma in an elderly patient: a case report. Archives of Gynecology and Obstetrics. 2008; 277: 471–474.

[13] Avritscher R, Iyer RB, Ro J, Whitman G. Lipoleiomyoma of the uterus. American Journal of Roentgenology. 2001; 177: 856.

[14] Karaman E, Çim N, Bulut G, Elçi G, Andıç E, Tekin M, et al. A Case of giant uterine lipoleiomyoma simulating malig-nancy. Case Reports in Obstetrics and Gynecology. 2015; 2015: 926961.

[15] Villanueva AJ, Martínez-Noguera A, Pérez C, Clotet M, Oliva E. Uterine myolipoma: CT and us. Abdominal Imaging. 1993; 18: 402–403.

[16] Loffroy R, Nezzal N, Mejean N, Sagot P, Krausé D. Lipoleiomy-oma of the uterus: imaging features. Gynecologic and Obstetric Investigation. 2008; 66: 73–75.

[17] Ghosh B, McKeown B, Gumma A. Lipoleiomyoma. BMJ Case Reports. 2011; 2011: bcr0820114577.

[18] Oppenheimer DA, Carroll BA, Young SW. Lipoleiomyoma of the uterus. Journal of Computer Assisted Tomography. 1982; 6: 640–642.

[19] Maebayashi T, Imai K, Takekawa Y, Sasaki J, Otsuka H, Katsura Y, et al. Radiologic features of uterine lipoleiomyoma. Journal of Computer Assisted Tomography. 2003; 27: 162–165.

[20] Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N. Significance of the “beak sign” in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Medical Journal. 2006; 53: 37–40.

[21] Tsushima Y, Kita T, Yamamoto K. Uterine lipoleiomyoma: MRI, CT and ultrasonographic findings. British Journal of Radiology. 1997; 70: 1068–1070.

[22] Prieto A, Crespo C, Pardo A, Docal I, Calzada J, Alonso P. Uterine lipoleiomyomas: us and CT findings. Abdominal Imaging. 2000; 25: 655–657.

[23] Lehrman BJ, Nisenbaum HL, Glasser SA, Najar D, Rosen M. Uterine myolipoma. Magnetic resonance imaging, computed to-mographic, and ultrasound appearance. Journal of Ultrasound in Medicin. 1990; 9: 665–668.

[24] Chibisheva V, Antovska V, Trajanova M, Dabeski D, Jovanovic R, Kijajova I. Vascular lipoleiomyoma of the uterus: an unusual case. Medical Archives. 2016; 70: 473–476.

[25] Akbulut M, Gündoğan M, Yörükoğlu A. Clinical and pathological features of lipoleiomyoma of the uterine corpus: a review of 76 cases. Balkan Medical Journal. 2014; 31: 224–229.

[26] Aung T, Goto M, Nomoto M, Kitajima S, Douchi T, Yoshinaga M, et al. Uterine lipoleiomyoma: a histopathological review of 17 cases. Pathology International. 2004; 54: 751–758.

[27] Kiuchi K, Hasegawa K, Ochiai S, Kosaka N, Kuroda H, Kaji Y, et al. Liposarcoma of the uterine corpus: a case report and literature review. Gynecologic Oncology Reports. 2018; 26: 78–81.

[28] Gaskin CM, Helms CA. Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. American Journal of Roentgenology. 2004; 182: 733–739.

[29] Sun S, Bonaffini PA, Nougaret S, Fournier L, Dohan A, Chong J, et al. How to differentiate uterine leiomyosarcoma from leiomyoma with imaging. Diagnostic and Interventional Imaging. 2019; 100: 619–634.

[30] Matsuda M, Ichimura T, Kasai M, Murakami M, Kawamura N, Hayashi T, et al. Preoperative diagnosis of usual leiomy-oma, atypical leiomyoma, and leiomyosarcoma. Sarcoma. 2014; 2014: 498682.

[31] Yamaguchi M, Kusunoki S, Hirayama T, Fujino K, Terao Y, Itakura A. Case of leiomyosarcoma arising from subserosal leiomyoma. Journal of Obstetrics and Gynaecology Research. 2019; 45: 1944–1947.

[32] Holzmann C, Saager C, Mechtersheimer G, Koczan D, Helmke BM, Bullerdiek J. Malignant transformation of uterine leiomy-oma to myxoid leiomyosarcoma after morcellation associated with ALK rearrangement and loss of 14q. Oncotarget. 2018; 9: 27595–27604.

[33] Mittal KR, Chen F, Wei JJ, Rijhvani K, Kurvathi R, Streck D, et al. Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Modern Pathology. 2009; 22: 1303–1311.

[34] Giannella L, Delli Carpini G, Montik N, Verdecchia V, Puccio F, Di Giuseppe J, et al. Ultrasound features of a uterine perivascular epithelioid cell tumor (PEComa): case report and literature review. Diagnostics. 2020; 10: 553.


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