Article Data

  • Views 1143
  • Dowloads 198

Case Reports

Open Access

Uterine lipoleiomyoma: a benign entity with malignant transformation potential?

  • Yunzhe Wan1,†
  • Xiang Zhang2,†
  • Yue Sun1
  • Linping Wang3
  • Guoyan Liu1,*,

1Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, 300052 Tianjin, China

2Department of Gynecology and Obstetrics, The First Affiliated Hospital of Henan University of Science and Technology, 471003 Luoyang, Henan, China

3Department of Gynecology and Obstetrics, Zhejiang Hospital, 310030 Hangzhou, Zhejiang, China

DOI: 10.31083/j.ejgo4302042 Vol.43,Issue 2,April 2022 pp.363-367

Submitted: 09 January 2021 Accepted: 23 February 2021

Published: 15 April 2022

*Corresponding Author(s): Guoyan Liu E-mail:

† These authors contributed equally.


Background: Uterine lipoleiomyoma is a rare lipomatous variant of uterine leiomyoma composed of a variable mixture of mature smooth muscle cells and adipocytes, typically found in peri or postmenopausal women. Malignancies arising from the tumor have rarely been reported though it is considered benign. Cases: We present three cases of uterine lipoleiomyoma and review literature to explore its etiology, characteristics, diagnosis and malignant transformation potential. Conclusion: Imaging examinations especially magnetic resonance imaging (MRI) play an important role in preoperative diagnosis. For large size and rapid growth of lipoleiomyoma, malignant transformation potential should be considered and surgery is required. Follow-up is still necessary.


Differential diagnosis; Magnetic resonance imaging; Malignancy; Ultrasound; Uterine lipoleiomyoma

Cite and Share

Yunzhe Wan,Xiang Zhang,Yue Sun,Linping Wang,Guoyan Liu. Uterine lipoleiomyoma: a benign entity with malignant transformation potential?. European Journal of Gynaecological Oncology. 2022. 43(2);363-367.


[1] Oh SR, Cho YJ, Han M, Bae JW, Park J, Rha S. Uterine lipoleiomyoma in peri or postmenopausal women. Journal of Menopausal Medicine. 2015; 21: 165–170.

[2] Scurry J, Hack M. Leiomyosarcoma arising in a lipoleiomyoma. Gynecologic Oncology. 1990; 39: 381–383.

[3] McDonald AG, Dal Cin P, Ganguly A, Campbell S, Imai Y, Rosenberg AE, et al. Liposarcoma arising in uterine lipoleiomy-oma: a report of 3 cases and review of the literature. American Journal of Surgical Pathology. 2011; 35: 221–227.

[4] Tyagi N, Tyagi R, Griffin Y. Uterine lipolemyoma. BMJ Case Reports. 2014; 2014: bcr2014207763.

[5] Terada T. Large lipoleiomyoma of the uterine body. Annals of Diagnostic Pathology. 2012; 16: 302–305.

[6] Raga F, Cholvi S, Esquembre MJ, Boigues D, Lucas C, Bonilla-Musoles F. Three-dimensional ultrasound radiance mode imaging of a uterine lipoleiomyoma. Medical Ultrasonography. 2016; 18: 247–249.

[7] Nayal B, Somal P, Rao A, Kumar P. Uterine lipoleiomyoma: a case report of a rare entity. International Journal of Applied and Basic Medical Research. 2016; 6: 134–136.

[8] Chu C, Tang Y, Chan TA, Wan Y, Fung K. Diagnostic challenge of lipomatous uterine tumors in three patients. World Journal of Radiology. 2012; 4: 58–62.

[9] Nazir HM, Mehta S, Seena CR, Kulasekaran N. Uterine lipoleiomyoma: a report of two cases. Journal of Clinical Imaging Science. 2017; 7: 26.

[10] Johari B, Koshy M, Sidek S, Hanafiah M. Lipoleiomyoma: a rare benign tumour of the uterus. BMJ Case Reports. 2014; 2014: bcr2014205814.

[11] Carvalho JF, Cubal A, Torres S, Morgado A, Oliveira C, do Carmo O. Preoperative diagnosis of a uterine lipoleiomyoma using transvaginal ultrasound: a case report of an unusual entity. Journal of Obstetrics and Gynaecology. 2014; 34: 281–282.

[12] Fujiwaki R, Ohnuma H, Miura H, Sawada K. Uterine lipoleiomyoma in an elderly patient: a case report. Archives of Gynecology and Obstetrics. 2008; 277: 471–474.

[13] Avritscher R, Iyer RB, Ro J, Whitman G. Lipoleiomyoma of the uterus. American Journal of Roentgenology. 2001; 177: 856.

[14] Karaman E, Çim N, Bulut G, Elçi G, Andıç E, Tekin M, et al. A Case of giant uterine lipoleiomyoma simulating malig-nancy. Case Reports in Obstetrics and Gynecology. 2015; 2015: 926961.

[15] Villanueva AJ, Martínez-Noguera A, Pérez C, Clotet M, Oliva E. Uterine myolipoma: CT and us. Abdominal Imaging. 1993; 18: 402–403.

[16] Loffroy R, Nezzal N, Mejean N, Sagot P, Krausé D. Lipoleiomy-oma of the uterus: imaging features. Gynecologic and Obstetric Investigation. 2008; 66: 73–75.

[17] Ghosh B, McKeown B, Gumma A. Lipoleiomyoma. BMJ Case Reports. 2011; 2011: bcr0820114577.

[18] Oppenheimer DA, Carroll BA, Young SW. Lipoleiomyoma of the uterus. Journal of Computer Assisted Tomography. 1982; 6: 640–642.

[19] Maebayashi T, Imai K, Takekawa Y, Sasaki J, Otsuka H, Katsura Y, et al. Radiologic features of uterine lipoleiomyoma. Journal of Computer Assisted Tomography. 2003; 27: 162–165.

[20] Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N. Significance of the “beak sign” in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Medical Journal. 2006; 53: 37–40.

[21] Tsushima Y, Kita T, Yamamoto K. Uterine lipoleiomyoma: MRI, CT and ultrasonographic findings. British Journal of Radiology. 1997; 70: 1068–1070.

[22] Prieto A, Crespo C, Pardo A, Docal I, Calzada J, Alonso P. Uterine lipoleiomyomas: us and CT findings. Abdominal Imaging. 2000; 25: 655–657.

[23] Lehrman BJ, Nisenbaum HL, Glasser SA, Najar D, Rosen M. Uterine myolipoma. Magnetic resonance imaging, computed to-mographic, and ultrasound appearance. Journal of Ultrasound in Medicin. 1990; 9: 665–668.

[24] Chibisheva V, Antovska V, Trajanova M, Dabeski D, Jovanovic R, Kijajova I. Vascular lipoleiomyoma of the uterus: an unusual case. Medical Archives. 2016; 70: 473–476.

[25] Akbulut M, Gündoğan M, Yörükoğlu A. Clinical and pathological features of lipoleiomyoma of the uterine corpus: a review of 76 cases. Balkan Medical Journal. 2014; 31: 224–229.

[26] Aung T, Goto M, Nomoto M, Kitajima S, Douchi T, Yoshinaga M, et al. Uterine lipoleiomyoma: a histopathological review of 17 cases. Pathology International. 2004; 54: 751–758.

[27] Kiuchi K, Hasegawa K, Ochiai S, Kosaka N, Kuroda H, Kaji Y, et al. Liposarcoma of the uterine corpus: a case report and literature review. Gynecologic Oncology Reports. 2018; 26: 78–81.

[28] Gaskin CM, Helms CA. Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. American Journal of Roentgenology. 2004; 182: 733–739.

[29] Sun S, Bonaffini PA, Nougaret S, Fournier L, Dohan A, Chong J, et al. How to differentiate uterine leiomyosarcoma from leiomyoma with imaging. Diagnostic and Interventional Imaging. 2019; 100: 619–634.

[30] Matsuda M, Ichimura T, Kasai M, Murakami M, Kawamura N, Hayashi T, et al. Preoperative diagnosis of usual leiomy-oma, atypical leiomyoma, and leiomyosarcoma. Sarcoma. 2014; 2014: 498682.

[31] Yamaguchi M, Kusunoki S, Hirayama T, Fujino K, Terao Y, Itakura A. Case of leiomyosarcoma arising from subserosal leiomyoma. Journal of Obstetrics and Gynaecology Research. 2019; 45: 1944–1947.

[32] Holzmann C, Saager C, Mechtersheimer G, Koczan D, Helmke BM, Bullerdiek J. Malignant transformation of uterine leiomy-oma to myxoid leiomyosarcoma after morcellation associated with ALK rearrangement and loss of 14q. Oncotarget. 2018; 9: 27595–27604.

[33] Mittal KR, Chen F, Wei JJ, Rijhvani K, Kurvathi R, Streck D, et al. Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Modern Pathology. 2009; 22: 1303–1311.

[34] Giannella L, Delli Carpini G, Montik N, Verdecchia V, Puccio F, Di Giuseppe J, et al. Ultrasound features of a uterine perivascular epithelioid cell tumor (PEComa): case report and literature review. Diagnostics. 2020; 10: 553.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time