Special Issue Title:

Hyperthermic Intraperitoneal Chemotherapy in Gynaecological Oncology 2022

Deadline for manuscript submissions: 31 May 2022

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Special Issue Editor

  • Guest Editor

    Christos Iavazzo, MDE-MailWebsite

    Gynaecological Oncology Department - Metaxa Cancer Hospital, Piraeus, Greece

    Interests: robotics; laparoscopic surgery oncology

Special Issue Information

Dear Colleagues,

The role of hyperthermic intraperitoneal chemotherapy (HIPEC) as a standard treatment procedure in the field of gynecologic oncology is controversial. Although widely discussed and studied as a subsidiary method of interval cytoreductive surgery, HIPEC is still being debated for the management of advanced and recurrent epithelial ovarian cancer (EOC). The results from many large trials support the safety and efficacy of HIPEC in well-selected EOC patients, where it has been shown to increase overall survival. Interestingly, recent findings support the effectiveness of HIPEC even when performed at the time of primary debulking surgery for stage III EOC patients in whom complete cytoreduction is anticipated. The results from large ongoing trials will soon be available. There are also promising results for HIPEC combined with adjuvant chemotherapy with platinum compounds in the management of advanced stage peritoneal-disseminated endometrial and cervical cancer. In patients with abdominally confined disease, HIPEC has been considered for peritoneal carcinomatosis of non-gynecological origin. Many authors have published evidence that supports explorative surgery followed by cytoreduction and HIPEC. Initially this was for cases of pseudomyxoma peritonei and malignant peritoneal mesothelioma, but was later followed by cases of gastric, colorectal and even breast cancer patients with pelvic peritoneal metastases.

Nevertheless, more prospective multi-center randomized studies are needed in order to draw conclusions about the safety of HIPEC and to determine which patients could benefit from its implementation. Further studies are also required to obtain robust data on the surgical procedures, the type and dose of chemotherapeutic regimens, and the temperature and duration of the hyperthermic arm needed to achieve optimal oncological outcomes. This information should help to support the recommendation of HIPEC in the gynecological cancer community.

The aim of this special issue is therefore to publish novel studies on the potential role of HIPEC in different gynecological cancers, through exploration of the indications, technique, and future challenges. We welcome authors to submit case reports, case series, retrospective studies, randomized trials and reviews in this field.


Prof. Dr. Christos Iavazzo

Guest Editor


Gynecologic cancer;Hysteroscopy;Cancer prevention;Early diagnosis;Cancer screening;Pre-operative cancer workup

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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