Deadline for manuscript submissions: 30 January 2023Print Special Issue Flyer (2)
Blood Transfusion Department, Affiliated Hospital of Jiangsu University, China
Interests: Breast Cancer; Tumor Microenvironment; Cancer Statistical Analysis; Cancer-Associated Fibroblasts(Cafs)
Gynecological malignant tumors, including not only cervical carcinoma, ovarian carcinoma, endometrial carcinoma of uterus, fallopian tubal adenomatoid tumor, but also breast cancer, seriously harm women's physical and mental health, and impose a serious social and economic burden. According to "Global Cancer Statistics 2020" published by Hyuna Sung et al in CA: A Cancer Journal for Clinicians, female breast cancer has overtaken lung cancer as the most common cancer in the world. With the continuous development of tumor microenvironment theory and the gradual deepening of related research, we have a new understanding of the occurrence, development, invasion, and metastasis of tumors. The occurrence of cancer is not just caused by tumor cells themselves, and it is closely related to the microenvironment of tumor cells. The tumor microenvironment was the internal environment in which tumors occur and develop. The so-called tumor microenvironment refed to a complex comprehensive system composed of various components affecting tumor genesis, growth, invasion, and metastasis, which is different from the microenvironment formed by normal cells and their surrounding tissues. It was mainly composed of tumor cells themselves, stromal cells, micro-vessels, lymphatic micro-vessels, tissue fluid, numerous cytokines, and a small number of infiltrating cells. Stromal cells include fibroblasts, immune and inflammatory cells, adipocytes, glial cells, smooth muscle cells, and some vascular cells. On the one hand, these stromal cells can be induced by tumor cells and produce a large number of growth factors, cellular chemokines, and stromal degradation enzymes around them, which were conducive to the proliferation and invasion of tumor cells. On the other hand, in the process of distant metastasis of tumor cells, these stromal cells were easy to form a special microenvironment suitable for the growth of tumor cells at the site of distant metastasis, which provides suitable soil for the survival and proliferation of tumor cells, thus promoting the distant metastasis of tumor cells. Therefore, the tumor microenvironment has been confirmed to play an important role in the occurrence, genesis, invasion, and metastasis of many kinds of tumors. Tumor microenvironment stromal cells and their production factors may be new targets for future antitumor drug design.
The theme of this special issue is concentrated on the understanding of the Gynecological Tumor microenvironment. It is not restricted to tissue, cell or molecular and genetic levels, it can be their clinical surveillance indicators, cross talk, signal pathway, and prediction analysis etc. Articles could be accepted by many forms, such as review, research paper, case report，short communications and etc.
Qiongle Peng, PhD
Gynecological Cancer; Tumor Microenvironment; Cancer Statistical Prediction Analysis; Tumor Surveillance Indicators
Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.
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