Deadline for manuscript submissions: 01 February 2023Print Special Issue Flyer (10)
The First Affiliated Hospital of Chongqing Medical University, China
Interests: Breast Cancer; Cancer Biomarkers
The First Affiliated Hospital of Dalian Medical University, China
Interests: Cancer Biology; Gene Therapy
Breast cancer is the most common cancer in women worldwide. Data from the Global Cancer Statistical Report shows that in 2020, breast cancer in women surpassed lung cancer for the first time to become the most common cancer in the world, with an estimated 2,261,419 new cases. At the same time, breast cancer is the fifth leading cause of cancer death globally, with 684,996 deaths. In recent years, the incidence and mortality of female breast cancer have risen sharply worldwide, and the burden of the disease has also increased, which has become a major global public health problem.
Nucleotides are the main building blocks of genetic material and are made up of purines (adenine and guanine) and pyrimidines (thymine, uracil, and cytosine). They are essential substances in DNA and RNA biosynthesis, cell signaling, enzymatic regulation and metabolism. Nucleotide metabolism in cancer cells is significantly higher than in normal cells, indicating that the replication and transcription of cancer cells' genetic material are enhanced considerably, providing favorable conditions for cancer cell proliferation and metastasis. Nucleotide synthesis ensures timely DNA replication, is essential for cancer cell proliferation, and is one of the critical elements of cancer metabolism. Therefore, nucleotide metabolism is a potential target for cancer therapy. Although many efforts targeting this attractive metabolic pathway have been reported, key enzymes' metabolic and regulatory mechanisms in nucleotide metabolism remain unclear. Exploring the critical molecules of nucleotides and the biological functions of nucleotide metabolism are expected to greatly improve cancer's clinical diagnosis and targeted therapy.
This special issue aims to organize original research and review articles exploring those promising nucleotide molecules and nucleotide metabolism-related anticancer targets, which may assist in the diagnosis and treatment of cancer, especially breast cancer, including experimental techniques and methods, as well as clinical validation and application.
Prof. Yingkun Xu and Prof. Guangzhen Wu
Breast Cancer; Nucleotides; Nucleotide Metabolism; Precision Medicine; Gene Therapy
Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.
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