Special Issue Title:

Biotechnologies, Imaging Modalities and Analysis Methodologies for Probing the Breast Cancer

Deadline for manuscript submissions: 01 June 2023

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Special Issue Editor

  • Guest Editor

    Yu Shang, PhDE-MailWebsite

    Professor, Department of Biomedical Engineering, North University of China, Taiyuan, China

    Interests: Biomedical Engineering

  • Guest Editor

    Shun Wan Chan, PhDE-MailWebsite

    Associate Professor, Head of Department of Food and Health Sciences, Technological and Higher Education Institution of Hong Kong, Chai Wan, Hong Kong, China

    Interests: Biotechnology

Special Issue Information

Dear Colleagues,

Breast cancer is the most threatening malignant tumor for women worldwide. According to the global cancer statistics, both the occurrence rate and mortality rate of breast cancer rank first among the female population, with 24.2% and 15.0% respectively. Early screening and identifying of breast cancer offer early opportunities for patients to receive timely treatments, thus elevating the survival rate and improving the life quality. 

Imaging modalities, such as X-ray mammography, breast ultrasonography, and magnetic resonance imaging (MRI), are the most frequently-used approaches for screening of breast cancers in clinic. Nevertheless, none of these modalities is ideal to combine multiple advantages such as high sensitivity and specificity, low cost as well as fast measurement. The biopsy test is the golden standard to identify the cancerous cells, which, however, due to the disadvantage of invasiveness, only serves as the last option for patients suffering from breast diseases. 

Seeking for the ideal approaches to probe breast cancer is always the effort for both scientists and clinicians. In recent year, a few technologies are emerging, as opposed to the conventional approaches, for probing the breast cancer, either invasively or noninvasively. For example, fluorescence technology has been developed to identify the cancer cells, which are known to overexpress Glut5, a sugar transporter accounting for the transfer of fructose across the cell membrane. Because Glut5 transporter is not overexpressed in healthy breast cells, the fluorescent-tagged fructose could be used to differentiate between healthy and cancerous cells. Another alternative for breast cancer detection is functional imaging. For example, the near-infrared diffuse optical/correlation tomography (DOT/DCT) have been developed to probe the abnormal tissue blood flow/oxygenation/oxygen metabolism. Because the cancerous cells are with the feature of abnormally higher metabolic demands, subsequently elevating the microcirculation and causing the poor oxygen status. Those functional abnormalities caused by the cancerous cells often appear earlier than the morphological changes that are detectable by the conventional imaging modalities. Hence, the functional imaging offers a new strategy for early screening of the breast cancer. 

In addition to the biotechnologies and imaging modalities mentioned above, the advanced data analysis methods are emerging, in recent years, with aim to assist the diagnosis of breast cancer through integrating a variety of measuring modalities and numerous parameters. The data analysis methods, particularly those combing with the artificial intelligence (AI), have promising potential for future detection of breast cancer. 

To promote the latest progress in the creation, development and clinical usage of various approaches for probing the breast cancer, we invite the submission of original research or review articles to Special Issue of European Journal of Gynaecological Oncology. This special issue is planned to cover all of the new principles, technologies, or applications of the possible methodologies or strategies that will benefit for diagnosis or earlier screening of the breast cancer.

Yu Shang, PhD and Shun Wan Chan, PhD

Guest Editors


Breast Cancer; Imaging; Biotechnology; Data Analysis

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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