Deadline for manuscript submissions: 24 June 2023Print Special Issue Flyer (2)
Biomedicum, Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Interests: Human Endometrium; Stem Cells; Decidualization; Polycystic Ovary Syndrome; Endometrial Cancer
Endometrial cancer (EC) is one of the most frequent and the fifth most common malignancies among all cancers with an increasing incidence in women. Most cases of EC are hormone-driven, and estrogen (E2) signalling through the estrogen receptor in particular seems to function as an oncogenic signal for EC development. Genes involved in cell cycle regulation, proliferation, and morphogenesis were also discovered to be linked to the early stages of myometrial infiltration in the formation of endometrioid cancer, according to data on global gene expression data. Additional important risk factors for EC in obese patients include higher chronic inflammation, decreased serum adiponectin levels, and insulin resistance.
Polycystic ovary syndrome (PCOS) is the most frequent heterogeneous endocrine disorder, with prevalence rates ranging from 5 to 20 percent. After ruling out other endocrine disorders, the National Institutes of Health (NIH) established the criteria for PCOS in 1990, necessitating the presence of chronic anovulation and clinical and/or biochemical evidence of hyperandrogenism (HA). Women with PCOS present with a three-to five-fold increased risk of EC. This risk is most likely explained by endometrial hormonal, metabolic, and inflammatory abnormalities. In fact, oligo-amenorrhea, unopposed E2, obesity, hyperandrogenism, hyperinsulinemia, inflammation, and genetic susceptibility are all risk factors for EC in women with PCOS. Indeed, approximately 70–80% of endometrial cancers are Type I (EC1) tumours and reported to be over-represented in PCOS. According to in vitro research, endometrial stromal cells from women with PCOS have an inflammatory character that may make them more susceptible to endometrial cancer. Overall, there is a lack of information regarding endometrial cancer in women with PCOS, and larger, more thorough studies are needed to evaluate the underlying mechanisms and risk profiles.
In this special issue, the risk of developing endometrial cancer in PCOS women should be focused on the molecular level in relation to aberrant endometrial milieu in these women.
Masuma Khatun, PhD
PCOS; Endometrial Hyperplasia; Endometrial Cancer; Unopposed Estrogen Effect; Progesterone Resistance; Endometrial Mesenchymal Stroma/Stem Cells; Obesity; Insulin Resistance; Hyperandrogenism; Inflammation
Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.
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