Special Issue Title:

The management of endometrial cancer

Deadline for manuscript submissions: 31 July 2023

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Special Issue Editor

  • Guest Editor

    Nicolae Gica, MD, PhDE-MailWebsite

    Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Interests: Gynecologic Oncology; Gynaecological Surgery; Endometriosis; Hysterectomy

  • Guest Editor

    Yoland Antill, BMed FRACP MDE-MailWebsite

    Medical Oncologist; Cabrini, Peninsula and Melbourne Health Services, VIC, Australia. Adjunct Associate Professor, Monash University, VIC, Australia

    Interests: Medical Oncology; Hereditary Cancer Syndromes; Breast Cancer; Gynaecological Cancers; Endometrial Cancer

Special Issue Information

Dear Colleagues,


Endometrial cancer is the most common of gynecological cancers affecting women in developed countries with rates also fast rising in developing nations. The increasing incidence of endometrial cancer relate to both an aging population but also to the increasing rates of obesity- one of the well-recognized risks for endometrial cancer. In addition, hereditary conditions including Lynch and Cowden’s Syndrome also contribute to endometrial cancer risk. There are four molecularly distinct subtypes of endometrial cancer using the TCGA classification model- each with their own prognostic implications and therefore impacts on treatment decisions. While most patients are managed with surgery, with a high likelihood of cure, there are women with endometrial cancer for whom surgical decisions remain difficult- in particular around fertility preservation, lymph node assessment and surgical benefit in those with extensive nodal involvement, or in those where co-existent significant obesity adds to surgical risks. Similarly adjuvant treatment guidelines exist, but with increasing complexity in who could be managed without adjuvant therapy and what therapies are effective in reducing risk of recurrence. In the setting of advanced endometrial cancer, combination platinum based therapy remains the gold standard for first line systemic therapy- but the recent expansion of understanding of the benefit of immune therapy (single agent or in combination) will this current standard be challenged- particularly in those with mismatch repair deficient tumors where responses to immune checkpoint inhibitors are more likely. The use of endocrine therapy remains mixed despite a large proportion of tumors expressing estrogen receptors. The overall prognosis for women with advanced disease remains very poor and therefore the scope for expanded therapeutics is high. 


The aim of this special edition is to focus on the management of endometrial cancer with the aim of improving outcomes for women with both early and advanced endometrial cancer. 


Nicolae Gica, MD, PhD and Yoland Antill, BMed FRACP MD

Guest Editors

Keywords

Endometrial Cancer; High-risk Factors; Adjuvant Treatment; Endocrine Therapy; Targeted Therapy

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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