Deadline for manuscript submissions: 31 October 2022Print Special Issue Flyer (2)
Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplantation, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
Interests: gynaecopathology; gynaecological oncology; molecular oncology; human papilloma virus; PAP smear; breast cancer; target therapy; precision oncology; endocrine disruptors
New imaging technologies, the application of diagnostic immunohistochemistry in histopathology, and the implementation of laparoscopic and robotic techniques in gynaecological surgery have led to excellent results in the diagnosis and intervention of gynaecological oncology. Furthermore, next-generation sequencing and bioinformatics have made it possible to simultaneously screen for the presence of mutations in hundreds of oncogenes. This can be done using in-depth solid biopsy, liquid biopsy or tumor samples from surgical specimens. Some mutated clones can be targeted by specific drugs, giving rise to the concept of precision oncology. In practice, however, more than one oncogenic mutation is nearly always found in high-grade aggressive tumor samples, meaning that full eradication is still a utopia. This is because effective drugs against all mutated oncogenes have yet to be developed. Moreover, a cure would require the co-administration of multiple drugs that may not be tolerated by the patient due to important side-effects. The solution to this problem currently represents one of the greatest challenges in gynaecological oncology. Another major challenge is the prevention of gynecological cancers associated with the Human Papilloma Virus. This can be achieved through the global expansion of effective and safe vaccination programs, with ready access even in low-income nations. In line with the 2030 Agenda, the final challenge is to significantly reduce the impact of pollution and endocrine disruptors on gynaecological and breast cancers by moving to sustainable development. The aim of this Special Issue is therefore to present expert contributions that aim to solve these major challenges in gynaecological oncology.
Prof. Luca Roncati
next-generation sequencing (NGS);massive parallel sequencing;bioinformatics;human papilloma virus (HPV);oncoviruses;vaccination;targeted therapy;precision oncology;endocrine disruptors;pollution
Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.
(This article belongs to the Special Issue Gynaecological Oncology: Challenges for the 21st Century)
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